Clozapine, an atypical antipsychotic agent, is highly effective in treatment-resistant schizophrenia; however, its major side effect is constipation. Instead of laxatives, rhein is a pharmacologically active component found in Rheum palmatum L., a medicinal herbal remedy for constipation. The purpose of this study is to determine whether rhein impacts the pharmacokinetics (PK) and pharmacodynam...

Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, and inflammatory disorders. In this study, we tested the effect of rhein, a lipophilic anthraquinone derived from a traditional Chinese herbal medicine Rheum palmatum L., on NAFLD-associated hepatic steatosis, insulin resistance, and the T helper (Th)1/Th2 cytokine imbalance in high-fat diet-induced obese (...

Since the significant public health hazard of Hepatitis B virus (HBV) infection and obvious drug resistance and dose-dependent side effects for common antiviral agents (e.g., interferon α, lamivudine, and adefovir), continuous development of agents to treat HBV infection is urgently needed. Traditional Chinese medicine (TCM) is an established segment of the health care system in China. Currentl...

Rheum emodi or Himalayan rhubarb is a perennial herb belongs to family Polygonaceae. It has been used in various traditional systems as laxative, tonic, diuretic and to treat fever, cough, indigestion, menstrual disorder since antiquity. This paper consists of literature of Rheum emodi regarding its ethnobotany, folkloric uses, chemical properties and pharmacological studies. The material was c...

3. SOLOMAN DH, KAVANAUGH AJ, SCHUR PH: American College of Rheumatology Ad Hoc Committee on Immunologic Testing: Evidence-based guidelines for the use of Immunologic tests: antinuclear antibody testing. Arthritis Rheum 2002; 47: 434-44. 4. GORDON T. ISENBURG D: The Endocrinologic Associations ofthe Autoimmune Rheumatic Diseases. Semin Arthritis Rheum 1987; 17: 58-70. 5. TEKTONIDOU MG, ANAPLIOUT...

Background & Aims: Plants contain high antioxidant activities due to their redox and the chemical properties are affluent in secondary metabolites such as phenols, flavonoids, and other components. Rheum turkestanicum Janisch is a plant from polygonaceae that is widely used for diabetes. At this project that is a part of national thesis, relative levels of antioxidant activity, total phenols, t...

ankylosing spondylitis and related spondyloarthropathies. Rheum Dis Clin North Am 1995;21:117–28. 2. D’Agostino MA, Breban M, Said-Nahal R, Dougados M. Refractory inflammatory heel pain in spondylarthropathy: a significant response to infliximab documented by ultrasound. Arthritis Rheum 2002;46:840–1. 3. Olivieri I, Padula A, Barozzi L. The enthesiopathy: clinical manifestations, imaging and tr...