For nearly 4 years a search has been conducted in our laboratories among materials of natural origin for agents having the ability to retard the growth of tumors. Early in the course of this in vestigation crude culture filtrates of the fungus Aspergillus fumigatus were found to retard the growth of the Crocker mouse sarcoma 180 and of the mammary adenocarcinoma E 0771 in mice (4). Meanwhile, K...

The aim of this study was to investigate the influence of pH, buffer species and ionic strength on the release mechanism of Glipizide (G) from matrix tablets containing chitosan and xanthan gum prepared by a hot-melt extrusion process. The release mechanisms were controlled by the solubility and ionic properties of the polymers. All directly compressed (DC) tablets prepared in this study also e...

The experiments examined the contributions of forebrain noradrenaline and environmental enrichment to recovery of place navigation ability in rats after hemidecortication in infancy or adulthood. Noradrenaline depletion did not affect recovery from neonatal hemidecortication, although the early hemidecortications did allow sparing of function relative to adult operates. Noradrenaline depletion ...

For nearly 4 years a search has been conducted in our laboratories among materials of natural origin for agents having the ability to retard the growth of tumors. Early in the course of this in vestigation crude culture filtrates of the fungus Aspergillus fumigatus were found to retard the growth of the Crocker mouse sarcoma 180 and of the mammary adenocarcinoma E 0771 in mice (4). Meanwhile, K...

The effect of the known inhibitors of iron uptake, n-butylamine and NH4Cl, was examined at the molecular level to more precisely define the mechanisms by which these lysosomotropic agents block iron uptake by rabbit reticulocytes. Utilizing a rapid pulse-chase technique to follow the handling of a cohort of 59Fe, 125I-transferrin bound to rabbit reticulocytes, both amines were observed to have ...

These days our society is combating against a neurodegenerative disease called Alzheimer’s disease which is an age-related dementia. The concern has become graver as the disease may not be a necessary outcome in the oldest old and may even thrive in an age of thirties or forties. Alzheimer’s impairs a person’s cognitive ability and gradually leads to loss of bodily functions, making them depend...

Thylakoid membranes, derived from chloroplasts, have previously been shown to retard fat digestion and lower blood glucose levels after oral intake. The purpose of the present study was to investigate the effect of thylakoid membranes on the passage of methyl-glucose, dextran and ovalbumin over rat intestine in vitro using Ussing chambers. The results show that thylakoids retard the passage of ...