How synapses change their strength in response to impinging neural activity is a fundamental issue for understanding how the brain molds its circuitry in response to behavioral experience. Although a growing number of studies reveal the involvement of postsynaptic changes contributing to synaptic plasticity in brain circuits, the involvement of presynaptic factors has been implied by several st...

We present a computational model of human performance on the Sustained Attention to Response Task, a computer-based task in which people must withhold responses to infrequent and unpredictable stimuli during a period of rapid and rhythmic responding to frequent stimuli. The model, formulated within the ACT-R cognitive architecture, accounts for human performance in terms of two competing strate...

in this paper the control algorithm for controlled civil structures subjected to earthquake excitation is thoroughly investigated. the objective of this work is the control of structures by means of the pole placement algorithm, in order to improve their response against earthquake actions. successful application of the algorithm requires judicious placement of the closed-loop eigenvalues from ...

Fast response, high luminescence contrast, three-dimensional (3D) storage, and nondestructive reading are key factors for the optical storage application of photochromic materials. Femtosecond (fs) laser direct writing technology with multiphoton nonlinear absorption is becoming a useful tool microprocessing functional units in 3D space glass owing to its remarkable advantages, such as fast pro...

Background: Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility in women of reproductive age, affecting 7% of this population. Although not entirely understood, the etiology of PCOS is closely linked to obesity and abdominal adiposity that are considered to worsen the clinical presentation, particularly menstrual irregularities and hyperandrogenism. Lifestyle mo...

In this article we examine four objections to the genetic modification of human beings: the freedom argument, the giftedness argument, the authenticity argument, and the uniqueness argument. We then demonstrate that each of these arguments against genetic modification assumes a strong version of genetic determinism. Since these strong deterministic assumptions are false, the arguments against g...

Neutrophils are the first cells of innate immune system that respond to infection by arriving at sites when pathogens have exceeded physical barriers. Among their response mechanisms against is release neutrophil extracellular traps (NETs), which composed deoxyribonucleic acid and antimicrobial proteins such as elastase, myeloperoxidase, peptides, other in granules. The formation considered an ...

Diese Dissertation wurde selbständig, ohne unerlaubte Hilfe erarbeitet.

The thioredoxin system, comprising thioredoxin (Trx), thioredoxin reductase (TrxR) and NADPH, is one of the major cellular antioxidant systems, implicated in a large and growing number of biological functions. Trx acts as an oxidoreductase via a highly conserved dithiol/disulfide motif located in the active site ( Trp-Cys-Gly-Pro- Cys-Lys-). Different factors are involved in the regulation of T...