N-(2-aminophenyl)-4-[N-(pyridine-3yl-methoxy-carbonyl) aminomethyl] benzamide (MS-275) is a second generation histone deacetylase (HDAC) inhibitor with significant anti-tumor efficacy currently in clinical development. We investigated the effect of MS-275 treatment on various colon cancer cell lines, as well as on mouse xenograft models derived from human colorectal cancer. MS-275 exerted stron...

These studies were carried out to investigate the potential helper T cell repertoire specific for the random copolymer poly(L-Glu55,L-Ala35, L-Phe9)n(GL phi 9) of responder, nonresponder, and (responder x nonresponder)F1 murine strains. We tested the ability of these T cells to collaborate with dinitrophenyl (DNP)-specific primary and secondary B lymphocytes of each strain in response to the an...

The purpose of this study was to investigate the effects of multiple infusions of allogeneic MSCs on glucose homeostasis and morphometry of pancreatic islets in high- fat diet (HFD) fed mice. Swiss mice were fed standard diet (C group) or HFD (HFD group). After 8 weeks, animals of HFD group received sterile phosphate-buffered saline infusions (HFD-PBS) or four infusions of MSCs one week apart (...

In this paper, we study user profile matching with privacy-preservation in mobile social networks (MSNs) and introduce a family of novel profile matching protocols. We first propose an explicit Comparison-based Profile Matching protocol (eCPM) which runs between two parties, an initiator and a responder. The eCPM enables the initiator to obtain the comparison-based matching result about a speci...

In this paper we present a wireless wearable body area system for locating, tracking and monitoring emergency responders in harsh and remote environments. Tracking an emergency responder and monitoring their vital signs using various medical sensors is important in supporting the safety of the emergency responder. This work is the preliminary step towards the development of a collaborative real...

Gender is rarely included as a factor in economics models. However, recent work in experimental economics, as well as in psychology and political science, suggests that gender is an important determinant of economic and strategic behavior. We examine gender differences in bargaining using the ‘‘trust game’’ introduced by Joyce Berg et al. (1995). In this two-person game, the ‘‘proposer’’ is giv...

Immunization of rabbits from a closed colony with streptococcal Group A-variant vaccines identified about two-thirds of them as low and heterogeneous responders. One-third of the rabbits showed a restriction of the response independent from the magnitude. Selective breeding from one monoclonal high-responder male and two restricted high-responder female rabbits succeeded in segregation of high-...

Lipopolysaccharide-enhanced secretion of non-immunoglobulin proteins by bone marrow cells derived from responder, nonresponder, and low-responder mouse strains did not precisely correlate with the lipopolysaccharide responsiveness assessment based on the mitogenic reactivity of splenocytes. These findings suggest that enhancement of secretion of non-immunoglobulin protein may be useful for furt...

In generating a conditional transgenic murine model based on a tetracycline-regulated system, we obtained unexpected patterns of expression due to the transcriptional inactivity of the tet-responder promoter. Here we show strong cell-type-restricted expression that was variegated to an extent determined by the number of responder transgene copies integrated into the host genome.

We provides an evaluation of non-parallelizable puzzles used to prevent DoS in authentication protocols. With an evaluation based on a simulation and performance analysis, this approach helps a responder to resist against DoS, as well as improves the throughput of services for legitimate clients. Another key strength is that the construction and verification at the responder is simple and fast.