نتایج جستجو برای: respectively sadeghiyeh

تعداد نتایج: 685954  

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2002
Xia Wen Jun-Sheng Wang Janne T Backman Jouko Laitila Pertti J Neuvonen

To evaluate the inhibitory effects of trimethoprim and sulfamethoxazole on cytochrome P450 (P450) isoforms, selective marker reactions for CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4 were examined in human liver microsomes and recombinant CYP2C8 and CYP2C9. The in vivo drug interactions of trimethoprim and sulfamethoxazole were predicted in vitro using [I]/([I] + K(i)) v...

2015
Kensaku Shojima Akira Sato Hideaki Hanaki Ikuko Tsujimoto Masahiro Nakamura Kazunari Hattori Yuji Sato Keiji Dohi Michinari Hirata Hideki Yamamoto Akira Kikuchi

Wnt5a activates the Wnt/β-catenin-independent pathway and its overexpression is associated with tumor aggressiveness enhancing invasive activity. For this action, Wnt5a-induced receptor endocytosis with clathrin is required. Wnt5a expression was previously believed to be associated with cancer cell motility but not proliferation. Recently, it was reported that Wnt5a is also implicated in cancer...

Journal: :The Journal of biological chemistry 2004
M Germana Sanna Jiayu Liao Euijung Jo Christopher Alfonso Min-Young Ahn Melissa S Peterson Bill Webb Sophie Lefebvre Jerold Chun Nathanael Gray Hugh Rosen

Sphingosine 1-phosphate (S1P) influences heart rate, coronary artery caliber, endothelial integrity, and lymphocyte recirculation through five related high affinity G-protein-coupled receptors. Inhibition of lymphocyte recirculation by non-selective S1P receptor agonists produces clinical immunosuppression preventing transplant rejection but is associated with transient bradycardia. Understandi...

2015
Qi-Lin Wang Shang-Jing Guo

IntroductIon According to the demographics, the world population over 60 years will double from 605 million to 2 billion people between 2000 and 2050. Aging is a complex process in which the organism and its ability to respond to external stresses become progressive decline. The degenerative aging process is the major underlying cause for aging‐related diseases, including hypertension, diabetes...

2015
Ge Song Renjie Wang Junfei Guo Xuyuan Liu Fang Wang Ying Qi Haiying Wan Min Liu Xin Li Hua Tang

miRNAs typically downregulate the expression of target genes by binding to their 3'UTR, and dysregulation of miRNAs may contribute to tumorigenesis. Here, we found that miR-346 and miR-138 competitively bind to a common region in the 3'UTR of hTERT mRNA and have opposite effects on the expression and function of hTERT in human cervical cancer cells. Furthermore, G-rich RNA sequence binding fact...

Journal: :The EMBO journal 2008
Stephanie Pebernard Lana Schaffer Daniel Campbell Steven R Head Michael N Boddy

The Smc5/6 holocomplex executes key functions in genome maintenance that include ensuring the faithful segregation of chromosomes at mitosis and facilitating critical DNA repair pathways. Smc5/6 is essential for viability and therefore, dissecting its chromosome segregation and DNA repair roles has been challenging. We have identified distinct epigenetic and post-translational modifications tha...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید