OBJECTIVES With increasing evidence that permanent tissue damage occurs early in the course of multiple sclerosis, it is important that treatment trials include patients in the earliest stages of the disease. For many patients with multiple sclerosis the first presentation is a clinically isolated syndrome. Not all patients with a clinically isolated syndrome develop multiple sclerosis, however...

Objective To investigate whether the strength of the association between magnetic resonance imaging (MRI) metrics and cognitive outcomes differs between various multiple sclerosis subpopulations. Methods A total of 1052 patients were included in this large cross-sectional study. Brain MRI (T1 and T2 lesion volume and brain parenchymal fraction) and neuropsychological assessment (Brief Interna...

how to cite this article: inaloo s, haghbin s, moradi m, dashti h, safari n. acquired cns demyelinating syndrome in children referred to shiraz pediatric neurology ward. iran j child neurol. 2014 spring; 8(2):18-23. objective incidence of cns acquired demyelinating syndrome (ads), especially multiple sclerosis (ms) in children, appears to be on the rise worldwide. the objective of this study wa...

Demyelinating and dysmyelinating white matter diseases are important components of neurological problems. Recently, Magnetic Resonance Imaging (MRI) has played a key role in diagnoses of white matter diseases. Therefore, the purpose of the current study is to evaluate the usefulness of MRI in determining the type and frequency of white matter disease. We studied 35 patients who visited the Radi...

Forty one moderately impaired patients with clinically confirmed multiple sclerosis (MS) and a relapsing-remitting course were submitted to a neuropsychological battery and magnetic resonance imaging (MRI) to correlate the neuropsychological performances with the degree of cerebral demyelination. The neuropsychological results were indicative of a very mild overall impairment. The patients were...

Introduction: Multiple Sclerosis (MS) is an auto-immune disease that involves central nervous system (CNS). Magnetic Resonance Spectroscopy (MRS) is an analytical non- invasive method for obtaining the pathologic data of disease and it brings biochemical information about studied tissue which can be helped in studying the reasons and development process of disease and it increa...

Understanding the intensity characteristics of brain lesions is key for defining image-based biomarkers in neurological studies and predicting disease burden outcome. In this work, we present a novel foreground-based generative method modelling local lesion that can both generate synthetic on healthy images synthesize subject-specific pseudo-healthy from pathological images. Furthermore, propos...

Latin America (LATAM) is a large region spanning North, Central, and South America, between latitudes 32 N and 56 S. The population of LATAM currently estimated at 625 million is predicted to grow to 779 million by 2050. LATAM is a genetically, ethnically, geographically, linguistically, economically, and racially diverse region, with an admixture of Amerindian, European, Asian, and African anc...