Graves' disease is a common cause of hyperthyroidism. Treatment options for Graves' disease include antithyroid medication, surgery or radioactive iodine (I-31) or RAI. This review will focus on the approach to RAI therapy; discussing dose selection, patient preparation, and consideration before and after administering RAI, examining aspects of pre-treatment with antithyroid medication as well ...

BACKGROUND The aim of the present work was to investigate the influence of lithium carbonate on the kinetics of radioiodine in the thyroid gland, and the long-lasting effect of radioiodine therapy pre-treated with lithium carbonate in patients with different types of hyperthyreosis and low baseline 24-h thyroidal radioactive iodine uptake (RAIU). MATERIAL AND METHODS The examinations were per...

BACKGROUND Treatment of differentiated thyroid cancer usually consists of a total thyroidectomy followed by one or several courses of radioiodine ((131)I). (131)I is known to have deleterious effects on radiation sensitive tissues and irradiation to the testes has been shown after its administration. We investigated effects of such treatment on sperm DNA in a patient with differentiated thyroid...

Radioiodine therapy is the safest, simplest, least expensive and most effective method for treatment of hyperthyroidism. The method employed in this research was a systematic bibliographic review, in which only valid studies or the clinically detailed enough open-labeled studies using validated scales were used. Iodine-131 (I-131) acts by the destructive effect of short-range beta radiation on ...

In thyroid cancer patients with renal impairment or other complicating factors, it is important to maximize I-131 therapy efficacy while minimizing bone marrow and lung damage. We developed a web-based calculator based on a modified Benua and Leeper method to calculate the maximum I-131 dose to reduce the risk of these toxicities, based on the effective renal clearance of I-123 as measured from...

objective: glioblastoma multiforme (gbm), one of the most common and aggressive malignant brain tumors, is highly resistant to radiotherapy. numerous approaches have been pursued to find new radiosensitizers. we used a picogreen and colonogenic assay to appraise the dna damage and cell death in a spheroid culture of gbm cells caused by iodine-131 (i-131) beta radiation in the presence of topote...

OBJECTIVE To present the case of a radioiodine therapy-naïve thyroid cancer patient with postthyroidectomy diplopia. CLINICAL PRESENTATION AND INTERVENTION A 63-year-old male patient presented with goiter. Histology performed after thyroidectomy proved follicular thyroid cancer. Without (131)I therapy, diplopia occurred from metastasis to the right medial rectus muscle. Improvement followed a...

i131 is a famous radio-iodine isotope in use for diagnosis and treatment of hyper functioning and cancerous thyroid gland. it is a nuclear reactor product; however nuclear reactor may be unavailable in some areas. replacement by i-124 may be possible, another iodine isotope producible by cyclotron; a system more available than reactor. here absorbed fraction of gamma and beta rays of i-124 thro...

Histologic variants (tall cell, columnar cell, diffuse sclerosing) of papillary thyroid cancer (PTC) have a worse prognosis, as do more invasive variants of follicular type. Intermediate risk of recurrence includes (1) microscopic invasion of tumor into the perithyroidal soft tissues, (2) cervical lymph node metastases, (3) I-131 uptake outside the thyroid bed, (4) aggressive histology, or (5) ...

Assessment of myocardial viability is deemed necessary to aid in clinical decision making whether to recommend revascularization therapy for patients with myocardial infarction (MI). Dianthraquinones such as hypericin (Hyp) selectively accumulate in necrotic myocardium, but were unsuitable for early imaging after administration to assess myocardial viability. Since dianthraquinones can be compo...