Background: Non-clinical and clinical studies showed efficacy of thrombomodulin alfa for disseminated intravascular coagulation, and its potential efficacy for severe sepsis and coagulopathy. Thrombomodulin alfa is excreted primarily via the kidney and renal function is known to affect the clearance. However the dosing adjustments for patients with renal dysfunction were not warranted, except f...

Objective: Dalbegia saxatilis (D.saxatilis) is used as a decoction in traditional medicine for ailments such as cough, small pox, skin lesions, bronchial ailments and toothache. This study is aimed at evaluating the toxic effect of methanol leaf extract of D.saxatilis on renal function. Materials and Methods: Wistar rats of both sexes were divided into four groups of five: control animals (grou...

introduction: during hemorrhagic shock (hs), the kidneys are one of the primary target organs involved. oxidative stress is shown to be enhanced in different models of acute kidney injury (aki). remote ischemic preconditioning (rpc) by brief limb ischemia is considered to be a safe method to protect different organs from further damage. in this study, we investigated the effects of brief hind l...

background serum creatinine as a classic marker of renal function has several limitations in the detection of renal dysfunction. objectives this study assessed the validity of serum cystatin c as a marker of renal function in critically ill patients with normal serum creatinine. patients and methods eighty adult patients referred to intensive care units with serum creatinine levels < 1.5 mg/dl ...

Objective(s): Infertility in varicocele may have an adverse outcome on the future life of an infertile male. This study was designed to investigate whether varicocele affects remote organs, including the kidney, liver, and brain. We have also evaluated the protective effects of NaHS administration on the structure and function of these organs.Material...

Currently, diabetes mellitus (DM) is a complex global problem, which increasing every year. So, in 2019, was detected 463 million adults (from 20 to 79 years old) the world. And main cause of death patients with cardiovascular complications. The study aimed investigate features functional and structural changes heart type 2 nephropathy. A total 98 were examined, out 78 had diabetic nephropathy ...

Experimental and clinical studies analyzing the impact of AVF on cardiovascular and renal parameters, as well as outcomes, in kidney transplant recipients are lacking. On the other hand, it is not known whether AVF ligation after transplantation modifies hemodynamic parameters and kidney function. We report a case of a renal transplant recipient who developed an acute congestive heart failure a...

BACKGROUND Massive liver necrosis, characteristic of acute liver failure, may affect hepatosplanchnic haemodynamics, and contribute to the alterations in renal haemodynamics and function. AIMS To investigate the relation between hepatosplanchnic haemodynamics, including portal systemic shunting, and renal blood flow and function in rats with acute liver failure. METHODS Liver failure was in...