Abstract Introduction Adenosine Deaminase (ADA) regulates extracellular levels of adenosine, a brain correlate sleep homeostasis. A single nucleotide polymorphism (SNP) the ADA gene (rs73598374) is known to be associated with increased homeostatic pressure for NREM after total deprivation (TSD). Whether this genotype effect also impacts REM TSD has not been systematically investigated. The limi...

Sleep is generally considered to be a recovery from prior wakefulness. The architecture of sleep not only depends on the duration of wakefulness but also on its quality in terms of specific experiences. In the present experiment, we studied the effects of restraint stress on sleep architecture and sleep electroencephalography (EEG) in different strains of mice (C57BL/6J and BALB/cJ). One object...

It is a common belief that sleep deprivation increases the susceptibility to diseases. In order to evaluate the effects of sleep deprivation on immune profile in humans, peripheral venous blood was obtained from sixteen healthy young male volunteers. Ten of the volunteers underwent 48 hours of sleep deprivation and the other six maintained their regular sleep schedule and acted as controls. The...

217 ACUTE SLEEP REDUCTION NORMALLY CAUSES A HOMEOSTATIC RESPONSE DURING THE NEXT SLEEP OPPORTUNITY, CHARACTERIZED BY INCREASED amounts of stage 3 and 4 (slow wave sleep [SWS])1,2 This increase occurs at the expense of REM sleep, stage 2 sleep, stage 1 sleep, and stage wake. The latter study also showed that spectral power density in the 0.5–8 Hz range increased but was most pronounced in the 0....

Background & Objective: Stress contributes to sleep-wake behavior in all animals. It seems that factors such as learning and memory processes can improve sleep disorders. Therefore, the present study was conducted to determine the effects of stress and learning (spatial memory) on total post-stress rapid-eye-movement (REM), non-rapid-eye-movement (NREM) and waking time in rats. Materials & Met...

Sleep is regulated by complex biological systems and environmental influences, neither of which is fully clarified. This study demonstrates differential effects of partial sleep deprivation (SD) on sleep architecture and psychomotor vigilance task (PVT) performance using two different protocols (sequentially) that each restricted daily sleep to 3 hours in healthy adult men. The protocols differ...

REM sleep enhances hippocampus-dependent associative memory but has little impact on striatal-dependent procedural learning1-3. Antidepressant medications like desipramine (DMI) inhibit rapid-eye-movement (REM) sleep but it is little understood how antidepressant treatments affect learning. We found that DMI strongly suppressed REM sleep in rats for several hours and impaired reconsolidation of...

S the paper published by Jenkins and Dallenbach in 1924 (1), a considerable number of studies have shown that sleep facilitates memory consolidation (reviews: [27]). Different paradigms have been applied to investigate the relationship between sleep and memory. First, the performances after equal periods of sleep versus wakefulness between acquisition and retrieval have been compared. The criti...

OBJECTIVE Arousal (AR) from sleep is associated with an autonomic reflex activation raising blood pressure and heart rate (HR). Recent studies indicate that sleep deprivation may affect the autonomic system, contributing to high vascular risk. Since in sleep disorders a sleep fragmentation and a partial sleep deprivation occurs, it could be suggested that the cardiovascular effects observed at ...

Upper airway dilator activity during sleep appears to be diminished under conditions of enhanced sleep propensity, such as after sleep deprivation, leading to worsening of obstructive sleep apnea (OSA). Non-rapid eye movement (NREM) sleep propensity originates in sleep-active neurons of the preoptic area (POA) of the hypothalamus and is facilitated by activation of POA warm-sensitive neurons (W...