The need for a long-term sustaining of optimal concentrations applied pesticides in the soil agriculture resulted development systems controlled release active substances. Such are based on use eco-friendly carrier materials that harmless to plants, humans and environment. Inorganic substances (e.g., clays or alike substances), biodegradable polymers natural synthetic origin, blends such their ...

The purpose of this study was to evaluate LC Bead LUMI™ (40-90µm and 70-150µm) in order to determine if their increased resistance to compression influences microsphere penetration and distribution compared to more compressible commercial microspheres. LC Bead LUMI™ 40-90µm and 70-150µm, LC BeadM1® 70-150µm, Embozene™ 40µm and Embozene™ 100µm size and distributions were measured using optical m...

The main objective of this study was to investigate biocompatibility and provide in-vivo pharmacological and toxicological evidence for further investigation of the possibility of pH sensitive ion exchange resin microsphere for clinical utilizations. Acute toxicity study and general pharmacological studies were conducted on the pH sensitive ion exchange resin microsphere we prepared. The genera...

The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of a highly water/soluble drug, salbutamol sulphate by (water in oil) in oil emulsion technique using ethyl cellulose as the retardant material. Various processing and formulation parameters such as drug/polymer ratio, stirring speed, volume of processing medium were optimized to maximize the e...

Nonunion is a common complication in open fractures and other severe bone injuries. Recombinant human bone morphogenetic protein-2 (rhBMP-2) delivered on a collagen sponge enhances healing of fractures. However, the burst release of rhBMP-2 necessitates supra-physiological doses of rhBMP-2 to achieve a robust osteogenic effect, which introduces risk of ectopic bone formation and severe inflamma...

Stimuli-responsive materials undergo structural changes in response to an external trigger (i.e., pH, heat, or light). This process has been previously used for a range of applications in biomedicine and microdevices and has recently gained considerable attention in controlled drug release. Here, we use a near-infrared (NIR) light responsive polymer-nanorod composite whose glass transition temp...

one small-scale double emulsion technique for incorporation of naja- naja oxiana venom into poly (lactide-co-glycolide) (plga) microspheres were developed and optimized. the effects of high speed homogenization on the double emulsion stability, microsphere size, entrapment efficiency and in vitro release of venom were studied. a stable double emulsion was verified by homogenization method. slow...

Microspheres are one of the novel drug delivery system and are formulated conveniently to obtain prolonged or controlled drug delivery to enhance the bioavailability and target drug to the specific sites. Ritonavir loaded ethylcellulose buoyant microspheres were formulated using ethylcellulose as rate retarding material. Buoyant microspheres were formulated by emulsion solvent diffusion method....