Heart failure is a clinical syndrome characterized by the inability of the heart to provide nutrient supply to tissues. In 75% of cases, the underlying pathology causing heart failure in patients with cardiac death is coronary heart disease. A rabbit model of heart failure with coronary ligation was produced to mimic coronary heart disease in humans. After producing the model, two arteries ...

Crocus sativus L. (saffron) is a widely used food additive for its color and taste. The hypotensive effects of saffron have been shown in previous studies. The aim of this study was to evaluate the mechanism of vasodilatory effects induced by saffron on isolated rat aorta.To study the vasodilatory effects of saffron aqueous extract (0.5, 1 and 2 mg/mL), isolated rat thoracic aorta rings were co...