Mutations in RYR1 encoding the ryanodine receptor (RyR) skeletal muscle isoform (RyR1) are a common cause of inherited neuromuscular disorders. Despite its expression wide range tissues, non-skeletal manifestations associated with mutations have only been rarely reported.Here, we report three patients diagnosis Central Core Disease (CCD), King-Denborough Syndrome (KDS) and Malignant Hyperthermi...