SUMMARY We now recognise that withdrawal symptoms from antidepressants are common, and can be severe long-lasting in some people. Many overlap with of anxiety or depression, making it difficult to distinguish relapse. describe how their onset soon after dose reduction, the association psychological physical symptoms, prompt response reinstatement, typical ‘wave’ pattern onset, peak resolution h...

Cocaine dependence continues to be a significant public health problem in the United States. Although some cocaine- dependent patients will respond well to drug counseling, for many, standard psychosocial treatment is inadequate. Therefore, the development of an effective medication for the treatment of cocaine dependence is a research priority. However, despite many years of research, no medic...

Duloxetine is a serotonin-noradrenaline reuptake inhibitor with established efficacy for the short-term treatment of major depressive disorder. Efficacy in continuation treatment (greater than six months of continuous treatment) has been established from both open and placebo-controlled relapse prevention and comparative studies. Seven published studies were available for review and showed that...

BACKGROUND After initially successful quit attempts, many people return to smoking within a year, reducing the public health benefits of investment in smoking cessation. We aimed to assess whether interventions designed to prevent relapse after a successful quit attempt reduce the proportion of recent quitters who return to smoking. METHODS We searched the Cochrane Tobacco Addiction Review Gr...

Purpose: To ascertain the role of social support and positive affect in prediction of addiction relapse. Materials and Methods: The research method was a causal-comparison. Population included all the clients seeking for medical advice in the centers for Addiction Treatment in Saravan and Iranshar. The sample includes 186 participants (83 participants had no relapse and 83 participants had...

CONTEXT Telephone-based disease management protocols have shown promise in improving outcomes in a number of medical and psychiatric disorders, but this approach to continuing care has received little study in alcohol- and drug-dependent individuals. OBJECTIVE To compare telephone-based continuing care with 2 more intensive face-to-face continuing care interventions. DESIGN A randomized 3-g...

IMPORTANCE Relapse is highly prevalent following substance abuse treatments, highlighting the need for improved aftercare interventions. Mindfulness-based relapse prevention (MBRP), a group-based psychosocial aftercare, integrates evidence-based practices from mindfulness-based interventions and cognitive-behavioral relapse prevention (RP) approaches. OBJECTIVE To evaluate the long-term effic...