P. F. Mastinu,1 M. Belkacem,1,9 M. D’Agostino,1 M. Bruno,1 P. M. Milazzo,1,2 G. Vannini,2 D. R. Bowman,7 N. Colonna,3 J. D. Dinius,6 A. Ferrero,4,8 M. L. Fiandri,1 C. K. Gelbke,6 T. Glasmacher,6 F. Gramegna,5 D. O. Handzy,6 D. Horn,7 W. C. Hsi,6 M. Huang,6 I. Iori,4 G. J. Kunde,6 M. A. Lisa,6 W. G. Lynch,6 G. V. Margagliotti,2 C. P. Montoya,6 A. Moroni,4 G. F. Peaslee,6 F. Petruzzelli,4 R. Rui,...

Over the past few years, novel pathogenic mechanisms leading to vascular inflammation and injury have been discovered. Circumstantial evidence that supports a pathogenic role for antineutrophil cytoplasmic antibodies (ANCA) in mediating vessel damage includes in vitro studies showing that ANCA promote neutrophil activation and endothelial injury. In addition, several animal models of ANCA-induc...

When cephalopod eggs were incubated in artificial sea water it was found that they sometimes resulted in hatchlings with defects of the statocyst suprastructure, leading to the severe behavioural defect of uncontrolled swimming. Experiments in defined media (seven basic salts mixed in deionized water) with seven species of cephalopods demonstrated clearly that there is 100% normal development o...

BACKGROUND A systems approach to understanding the etiology of schizophrenia requires a theory which is able to integrate genetic as well as neurodevelopmental factors. PRESENTATION OF THE HYPOTHESIS Based on a co-localization of loci approach and a large amount of circumstantial evidence, we here propose that a functional deficiency of glial growth factors and of growth factors produced by g...

Allelic variation in the size of the insulin (INS) variable number tandem repeat (VNTR) correlates with the expression of both INS in the pancreas and thymus and IGF2 (the gene downstream of INS) in the placenta. In addition, the shorter, class I alleles are associated with type 1 diabetes, whereas the longer, class III alleles are associated with type 2 diabetes, polycystic ovary syndrome (PCO...

objective(s) the central nucleus of the amygdala (cea) is a forebrain structure which is important in regulation of ingestive behavior and there is direct and circumstantial evidence to indicate that some circuits involved with feeding behavior include glutamatergic elements. the present study examined whether administration of nma (n-methyl-dl-aspartic acid) or mk801 into the cea altered water...

The use of Engineered Wood Systems (EWS) as structural alternatives or complements traditional materials, such steel and concrete, is growing interest acceptance in the architecture, engineering, construction industries. Gathering evidence from Australian context, this paper proposes a roadmap for adoption EWS primary materials medium-rise buildings, with scope increasing levels public awarenes...

nowadays, technological development and the appearance of new informational and communicational devices have been lead to new methods for communication and generating and storing of data. the growth of using of these methods in commercial and daily connection has caused a new version of evidence called electronic evidence. although the nature of electronic and paper evidence are different, the ...

Exploration of the specific role of cystine in the postexponential growth of Streptococcus faecalis led to an inquiry into the fate of cellular coenzyme A (CoA) and acyl carrier protein (ACP), both of which depend for their biosynthesis on cystine and pantothenate as precursors. In S. faecalis cells labeled by growth in the presence of (14)C-pantothenate, the label could be separated on the bas...

In Pretext in Peril, Professor Martin examines the interplay between procedural and substantive law in disparate treatment cases in which plaintiffs offer circumstantial evidence – evidence of pretext – as opposed to direct evidence to maintain their employment discrimination claims. Pretext constitutes an evidentiary showing that the defendant’s asserted reason for an adverse employment action...