BACKGROUND As genome-wide association efforts, such as CARDIoGRAM and METASTROKE, are ongoing to reveal susceptibility loci for their underlying disease-atherosclerotic disease-identification of candidate genes explaining the associations of these loci has proven the main challenge. Many disease susceptibility loci colocalize with DNA regulatory elements, which influence gene expression through...

conclusions the changes of treg and th17 cells and their associated cytokines were related to virological and biochemical responses. results in complete and partial-responders, treg cells frequencies and il-10, tgf-β1, il-23 levels were all decreased significantly after na therapy, while th17 cells and the il-17 levels were increased slightly. treg/th17 ratio was only dramatically declined in c...

background: regulatory t cells (tregs) have been involved in impaired immunity and may have a pivotal role in persistence of viral infections. objective: to develop a simple and reliable in-house three color flow cytometery of peripheral blood to understand the role of hcv infection in the increase of tregs. methods: the level of naturally occurring cd4+cd25+foxp3+ regulatory t cells (ntregs) i...

signal regulatory proteins (sirp) belong to immunoglobulin super family (igsf) and relate to integrin signaling cascades. it has been shown that sirpa is expressed in a variety of cells including myeloid cells and neurons. in the present study the expression of this igsf member in articular chondrocytes was investigated. methods: using a panel of anti-sirpalpha antibodies, immunohistochemistry,...

immune thrombocytopenic  purpura (itp) is an autoimmune bleeding disorder characterized by production  of auto-antibodies against platelet antigens. it is obvious that regulatory t cells (tregs) have a major role in controlling immune homeostasis and preventing autoimmunity. to investigate the frequency and functions of tregs, twenty itp patients and twenty age- and sex- matched healthy control...

abstract background and aims: vitamins are essential constituents of our diet that longley have been known to influence the immune system. vitamin d3 and b9 have received particular attention in recent years as these vitamins have been shown to have an unexpected and crucial effect on the immune response. 1, 25(oh)2d3 metabolizing enzymes and vitamin d receptor (vdr) are present in many cell ty...

Identifying the genomic regions and regulatory factors that control the transcription of genes is an important, unsolved problem. The current method of choice predicts transcription factor (TF) binding sites using chromatin immunoprecipitation followed by sequencing (ChIP-seq), and then links the binding sites to putative target genes solely on the basis of the genomic distance between them. Ev...

Microbes can tailor transcriptional responses to diverse environmental challenges despite having streamlined genomes and a limited number of regulators. Here, we present data-driven models that capture the dynamic interplay of the environment and genome-encoded regulatory programs of two types of prokaryotes: Escherichia coli (a bacterium) and Halobacterium salinarum (an archaeon). The models r...

in this paper, the development of a new potassium carbonateon alumina support sorbent prepared byimpregnating k2co3 with an industrial grade of al2o3 support was investigated. the co2 capturecapacity was measured using real flue gas with 8% co2 and 12% h2o in a fixed-bed reactor at atemperature of 65 °c using breakthrough curves. the developed sorbent showed an adsorptioncapacity of 66.2 mgco2/...

reducing co2 emission and lowering the concentration of greenhouse gases in the atmosphere has quickly become one of the most urgent environmental issues. while a variety of technologies and methods have been developed, the separation of co2 from gas streams is still a critical issue. apart from establishing new techniques, the exploration of membrane materials with high separation performance ...