As an anaerobic butyrate-producing bacterium, Clostridium cellulovorans can secrete a variety of extracellular enzymes to degrade plant-based cellulose. However, with glucose as the carbon source, it still secretes large amount protein in broth. The metabolism and regulation are obscure need be further studied. Hence, this study, C. was used conduct fed-batch fermentation microcrystalline at pH...

Little is known about the regulation of nonapoptotic cell death. Using massive insertional mutagenesis of haploid KBM7 cells we identified nine genes involved in small-molecule-induced nonapoptotic cell death, including mediators of fatty acid metabolism (ACSL4) and lipid remodeling (LPCAT3) in ferroptosis. One novel compound, CIL56, triggered cell death dependent upon the rate-limiting de novo...

Abstract Cells alter their metabolic state in response to changes nutrient availability through the induction of transcriptional programs that affect levels transporters and enzymes. Cell-intrinsic mechanisms sensing are intimately linked adaptive responses play critical roles shaping complex dynamic environment a growing tumor. We aim understand how food composition, combination with alcohol c...

Almost half of cancer patients experience cachexia syndrome. Cachexic patients are at risk of increased side effects of chemotherapy, reduced tolerance to chemotherapy drugs, longer duration of treatment period, and decreased quality of life. Cancer cachexia is a multifactorial syndrome. Micro ribonucleic acid (miRNA), a “non-coding RNA”, is considered to be a risk factor of cachexia and muscle...

Abstract Elucidating the relationship between cellular metabolism and T cell function has substantially advanced our understanding of how cells are regulated in response to activation. The metabolic profiles circulating or peripheral have been well-described, yet less is known regarding complex local microenvironments shape modulate bioenergetic profile tissue-resident lymphocytes. Intraepithel...

Cellular metabolism plays a central role in the regulation of both innate and adaptive immunity. Immune cells utilize metabolic pathways to modulate cellular differentiation or death. The intricate interplay between immune response is critical for maintaining homeostasis effective antiviral activities. In recent years, immunometabolism induced by viral infections has been extensively investigat...

Fat and carbohydrate are the major energy substrates during aerobic exercise in well-fed humans. The regulation of fat metabolism during exercise has not been as thoroughly studied as carbohydrate metabolism, especially in human skeletal muscle. Traditionally, it was believed that the regulation of skeletal muscle fat metabolism was mainly at the level of the delivery of free fatty acids to the...