نتایج جستجو برای: regorafenib
تعداد نتایج: 831 فیلتر نتایج به سال:
Background The objective of this study is to evaluate the efficacy and safety different third-line treatment regimens for metastatic colorectal cancer (mCRC) through a comprehensive analysis network meta-analysis (NMA). Additionally, aims provide guidance on selecting appropriate systemic patients with mCRC. Methods We conducted search PubMed, Embase, Web Science, Cochrane Central Register Cont...
Methods:We have tested, in vitro and in vivo, the effects of regorafenib, a novel oral multikinase inhibitor that targets protein kinases involved in tumor angiogenesis [VEGFR1–3 and tyrosine kinase with immunoglobulin and epidermal growth factor homology domain 2 (TIE2)], oncogenesis (KIT, RET and RAF) and the tumor microenvironment [plateletderived growth factor receptor-b and fibroblast grow...
Prior tumor cell studies have shown that the drugs sorafenib (Nexavar) and regorafenib (Stivarga) reduce expression of the chaperone GRP78. Sorafenib/regorafenib and the multi-kinase inhibitor pazopanib (Votrient) interacted with sildenafil (Viagra) to further rapidly reduce GRP78 levels in eukaryotes and as single agents to reduce Dna K levels in prokaryotes. Similar data were obtained in tumo...
Trifluridine/tipiracil and regorafenib: new weapons in the war against metastatic colorectal cancer.
Colorectal cancer (CRC) is the second leading cause of cancer-related death in the United States. Approximately 20% of patients have metastatic disease at diagnosis, and a vast number of these patients die within 5 years. The advent of modern chemotherapeutics has improved median overall survival for these patients; nonetheless, we must keep striving for better outcomes. Trifluridine/tipiracil ...
Drugs and other chemicals frequently bind nonspecifically to the constituents of an in vitro incubation mixture, particularly the enzyme source [e.g., human livermicrosomes (HLM)]. Correction for nonspecific binding (NSB) is essential for the accurate calculation of the kinetic parameters Km, Clint, and Ki. Many tyrosine kinase inhibitors (TKIs) are lipophilic organic bases that are nonionized ...
Drugs and other chemicals frequently bind nonspecifically to the constituents of an in vitro incubation mixture, particularly the enzyme source [e.g., human liver microsomes (HLM)]. Correction for nonspecific binding (NSB) is essential for the accurate calculation of the kinetic parameters Km, Clint, and Ki. Many tyrosine kinase inhibitors (TKIs) are lipophilic organic bases that are nonionized...
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