Relationships between regional myocardial perfusion and transmural function, both during treadmill exercise and at rest, were examined in conscious dogs with varying degrees of coronary stenosis produced by a hydraulic occluder. In 13 dogs we measured myocardial blood flow with microspheres (10-12 /tm in diameter) and regional systolic wall thickening (%). During exercise with coronary stenosis...

Background Wall motion together with the development of intracavity pressure and inside shear stress cause synchronous myocardial contraction and relaxation, as well as blood flow. These variables are related to cardiovascular function and disease. Assessing regional wall velocities and blood flow may therefore provide quantitative information regarding abnormalities in wall contractility and a...

The clinical complexity of sepsis and the regional variability in renal blood flow present a difficult challenge for the clinician or investigator in understanding the role and clinical importance of reduced blood flow in the pathophysiology of sepsis-induced acute renal failure. Understanding the role of regional microvasculature flow and interactions between endothelium and white blood cells ...

To evaluate possible disorders of regional myocardial blood flow in patients with chest pain syndromes and normal coronary arteriograms, we studied 21 patients with intracoronary injections of Xenon-133. Thirteen patients were restudied during an intervention: 6 patients received glyceryl trinitrate and 7 patients had contrast agent-induced hyperaemia. Patients were divided into 3 clinical grou...

The effect of reducing systemic arterial pressure with an arteriovenous fistula on left and right ventricular myocardial blood flow was studied in 17 anaesthetised, open chest, autonomically blocked dogs. Global and regional myocardial blood flows were measured with radioactive microspheres. As mean arterial pressure was reduced from 133 mmHg to 78 mmHg left ventricular myocardial blood flow an...

A new approach to the assessment of regional myocardial blood flow and fractional oxygen extraction has been developed using 15O-water (H2-15O) and 15O-hemoglobin (15O-Hb). Bolus doses (1 mCi) of H2-15O and 15O-Hb were injected 10 minutes apart into the left main coronary artery of 12 normal dogs. Sequential images of regional myocardial tracer clearance were obtained over 5 minutes with a posi...

Objectives: There has been no method which can measure regional myocardial blood flow in real-time and continuously. The purpose of this study was to validate myocardial blood flow measurement using a thermal diffusion method. For this purpose, myocardial blood flow measurement was performed using the thermal diffusion method and the electrolytic hydrogen clearance method. Methods: Seven pigs w...