INTRODUCTION The American Association of Endodontists clinical considerations for regenerative therapy (April 2015) advise of the risk of the possible adverse effect of staining of teeth. It is widely acknowledged that before these guidelines were developed there was no standardized protocol for regenerative therapy, and different approaches using different materials have been reported. The pur...

At present, cardiac diseases are a major cause of morbidity and mortality in the world. Recently, a cell-based regenerative medicine has appeared as one of the most potential and promising therapies for improving cardiac diseases. As a new generational cell-based regenerative therapy, tissue engineering is focused. Our laboratory has originally developed cell sheet-based scaffold-free tissue en...

On November 20th 2014, the Japanese legislature passed the new Act on the Safety of Regenerative Medicine (ASRM) and the revised Pharmaceuticals, Medical Devices, and Other Therapeutic Products Act (PMD Act) [1]. It is hard to make that sentence sound exciting, but what many outsiders have yet to fully appreciate is the tectonic shift in Japanese pharmaceutical regulatory policy this represents...

This paper overviews the present status on therapy of regenerative medicine which is based on tissue engineering. Tissue engineering is a biomedical form which enables cells to promote their proliferation and differentiation, resulting in induction of tissue regeneration. The scaffold of 3-dimensional porous material for cells with or without the controlled release system of growth factor is ap...

Large periapical defects may adversely affect the success rate of endodontic surgery. Use of regenerative therapy may enhance the prognosis of such teeth. A case of traumatized upper anterior teeth with infected radicular cyst and associated sinus tract reported to the dental hospital. A periradicular surgical procedure was performed to remove the nonhealing pathological tissue. To augment the ...

Advances in regenerative therapy have sparked significant interest the field of auricular reconstruction for congenital microtia. Congenital microtia is a rare deformity characterized by underdevelopment or absence external ear. Traditional surgical approaches using autologous grafts artificial implants limitations. Regenerative offers innovative solutions leveraging tissue engineering, biomate...

Regenerative periodontal therapy aims at reconstitution of the lost periodontal structures such as new formation of root cementum, periodontal ligament and alveolar bone. Findings from basic research indicate that enamel matrix protein derivative (EMD) has a key role in periodontal wound healing. Histological results from animal and human studies have shown that treatment with EMD promotes peri...

OBJECTIVES We investigated the effects of electrical stimulation therapy on cutaneous and muscle blood flow in critical limb ischemia patients following regenerative therapy. METHODS Three groups were studied: 10 healthy young subjects, 10 elderly subjects, and 7 critical limb ischemia patients after regenerative therapy. After 5 min rest, electrical stimulation was applied at 5 Hz on the tib...

Contemporary endodontics and the future of endodontics are based on regenerative strategies. Success of these regenerative endodontic treatments depends on disinfection of the root canal system. Current research in endodontics focuses on identifying the optimal methods of disinfection of root canal systems to achieve predictable results in revascularization therapy. Although the use of sodium h...

Recent findings in stem cell biology have opened a new window in regenerative medicine. The endometrium possesses mesenchymal stem cells (MSCs) called endometrial stem cells (EnSCs) having specific regenerative properties linked to adult stem cells. They contribute in tissue remodeling and engineering and were shown to have immuno-modulating effects. Many clinical trials were undertaken to asce...