F ascination with the ability to regenerate tissues and organs has existed since the earliest observations of Prometheus, Thevenot, and Tremblay. However, what might be called the modern era of tissue engineering and regenerative medicine began only a quarter century ago. The initial focus of a newly defined scientific discipline referred to as “tissue engineering” involved the ex vivo creation...

One of the major challenges in the field of regenerative medicine is how to optimize tissue regeneration in the body by therapeutically manipulating its natural ability to form scar at the time of injury or disease. It is often the balance between tissue regeneration, a process that is activated at the onset of disease, and scar formation, which develops as a result of the disease process that ...

Stem cell treatment and platelet-rich plasma (PRP) therapy are two significant issues in regenerative medicine. Stem cells such as bone marrow mesenchymal stem cells, adipose-derived stem cells and periodontal ligament stem cells can be successfully applied in the field of tissue regeneration. PRP, a natural product isolated from whole blood, can secrete multiple growth factors (GFs) for regula...

Despite decades of basic research, biliary diseases remain prevalent, highly morbid, and notoriously difficult to treat. We have, however, dramatically increased our understanding of biliary developmental biology, cholangiocyte pathophysiology, and the endogenous mechanisms of biliary regeneration and repair. All of this complex and rapidly evolving knowledge coincides with an explosion of new ...

The basic strategy of rehabilitation for regeneration of spinal cord nerve Fumihiro Tajima, M.D., Ph.D. and Takeshi Nakamura, M.D., Ph.D. Department of Rehabilitation Medicine Wakayama Medical University, School of Medicine (Clin Neurol 2013;53:1183) 和歌山県立医科大学リハビリテーション科〔〒 641-8509 和歌山市紀三井寺 811-1〕 (受付日:2013 年 5 月 31 日)

1 Department of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Amalia Children’s Hospital, Radboud University Medical Center, Nijmegen, Netherlands, 2 Department of Medical Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland, 3 Medical Protein Chemistry, Department of Translational Medicine, Lund Un...

hyaline cartilage is a vascular and neural tissue with scanty chondrocytes and limited regenerative ability. after some serious injuries of the cartilage, healing process will take place through the formation of fibrocartilage structures. currently, tissue engineering and cell therapy are 2 interesting therapeutic fields dealing with regenerative medicine. in this regard, tissue regeneration ha...

Large-area craniofacial defects remain a challenge for orthopaedists, hastening the need to develop facile and safe tissue engineering strategy; osteoconductive material combination of optimal growth factors microenvironment should be considered. Faced with unmet need, we propose that abundant cytokines chemokines can secreted from bone defect, provoking infiltration endogenous stem cells assis...

Abstract Digital light processing (DLP)‐based bioprinting technology has recently aroused considerable concerns as a strategy to deliver biomedical materials and/or specific cells create sophisticated structures for various tissue modeling and regeneration. In this review, we display concise introduction of DLP bioprinting, further discussion on the design manufacture (bio)printer with varied b...

Neurodegenerative diseases, such as Alzheimer's, Parkinson's, and spinal cord injuries amongst others pose significant challenges to modern Medicine. Traditional treatments often focus on symptom management rather than targeting the root causes of these conditions. However, advent Neuroregenerative Medicine represents a cutting-edge field that aims at restoring structure function nervous system...