treatment of severe immune thrombocytopenic purpura (itp) accompanied by life-threatening bleeding events is challenging and a combination of treatment measures should be undertaken to rapidly increase the platelet count. herein, we report a case of severe itp in a seven-year-old boy who suffered from massive bleeding which was totally unresponsive to conventional therapeutic interventions. sin...

background: the induction chemotherapy regimen for acute myeloid leukemia has evolved as once induction is completed patients progress through the consolidation phase and achieve remission in 76% of cases. for patients with relapsed or refractory disease, alternative chemotherapy agents are available. monoclonal antibody therapy with biological agents, such as the immunotoxin gemtuzumab ozogami...

Bio-oxidation of refractory sulfidic gold minerals has been applied at the commercial scale as a pre-treatment to improve yields and reduce chemical consumption during cyanidation. In this study, effect initial cell concentration on oxidation pyritic ore was evaluated with four aerated bioreactors 30 °C 10% pulp density pH maintained 1.4 NaOH. Results NaOH changes in soluble Fe S concentrations...

A previous study showed that negatively charged gold nanoparticles block ion pores by binding to the sulfur group of the cysteine loop of the ion channel when small molecules like amine lead the nanoparticles inside the ion pore. Cells were voltage clamped at -100 mV. Subsequently a bath application of 30 μM Ach produced a current followed by the extracellular application of 100 mM spermidine a...

objective: the aim of this study was to evaluate the effect of premenstrual syndrome (pms) treatment with selective serotonin reuptake inhibitor (ssri) on treatment response of refractory hypertension of the patients. method: this was a triple-blind randomized clinical trial conducted on female patients suffering from refractory hypertension and pms at the same time. we obtained informed consen...

purpose: to determine the outcomes of visual correction with femto-lasik following pk. methods: in this prospective study, 34 eyes of 31 patient who had undergone thin – flap lasik due to high refractive error after corneal grafting were evaluated .after complete ocular examination and assessment of uncorrected and corrected distant visual acuity (ucva and bcva) , the patients underwent femto-l...

Several techniques enable to inject intracellularly neurons with dyes and to use light and electron microscopy to correlate the physiological data with the morphological properties of the neuron. However, the ultrastructure of the neuron is usually obscured by the injected dye thus notably precluding the analysis of the postsynaptic specialisation and that of the other organelles. To overcome t...

The template-stripping method can yield smooth patterned films without surface contamination. However, the process is typically limited to coinage metals such as silver and gold because other materials cannot be readily stripped from silicon templates due to strong adhesion. Herein, we report a more general template-stripping method that is applicable to a larger variety of materials, including...