[1] We present a high-resolution climate record from a sediment core spanning an 80-kyr interval of time during the mid-Pliocene epoch, when warmer conditions and lower global ice volume prevailed worldwide. Oxygen and carbon isotope analyses were made on benthic and planktonic foraminifera from ODP Site 981 in the North Atlantic. The amplitude and approximate recurrence interval of suborbital ...

Parameter and state estimation problems are encountered when modeling processes that involve uncertain quantities to be estimated from measurements. In this paper, it is assumed that all uncertain quantities (state perturbation, measurement noise, parameter vector. . .) are bounded and belong to known sets. Many tools are available for characterizing the set of all values of the parameter or st...

In their invited narrative review article, Gionchetti et al (April-June issue) [1] report 6 studies in which probiotics were used for maintenance of remission in pouchitis or induction of remission in acute pouchitis. In all but one studies VSL#3 probiotic was used. In 4 studies treatment group (VSL#3 regimen was used in 3 studies) was compared to a control group [2-5]. [Q1. references are miss...

BACKGROUND Accurate measurement of the QT interval is very important from a clinical and pharmaceutical drug safety screening perspective. Expert manual measurement is both imprecise and imperfectly reproducible, yet it is used as the reference standard to assess the accuracy of current automatic computer algorithms, which thus produce reproducible but incorrect measurements of the QT interval....

The number of citations to previous work of an individual scientist has been considered, in part, to be an important indicator of academic performance in research. Some of these citations, of course, are to the author’s own work; the Germans call this “Eigenlob,” or self-praise. We analyzed data obtained from 340 papers (294 original articles and 46 review papers) in a sample of leading biomedi...