BACKGROUND Severe skin rash as toxicity of erlotinib has been reported in relation to better response and survival. However, some patients require dose reduction due to skin toxicities, and their prognosis remains uncertain. We retrospectively evaluated the clinical course of non-small cell lung cancer patients receiving erlotinib at a reduced dose because of skin rash. PATIENTS AND METHODS A...

background: the shielding methods in radiotherapy due to delivering an accurate radiation dose to cancer tissues and avoiding unnecessary dose to normal tissues are very important. these methods include lead standard blocks, individual molding and multi leaf collimator (mlc). the mlc method is not still common in iran radiotherapy centers. individual molding is better than the lead block shield...

Registered dose of herbicides may be higher than rate required for controlling weed species depending on growth stages. In order to study the effect of individual post-emergence application of 2,4-D plus MCPA and three sulfonylurea herbicides at four- to six-true leaf stage of weeds, experiments were conducted in 2011 at the greenhouse of Agricultural Faculty of Ferdowsi University of Mashh...

Introduction: Attention deficit and hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adolescents. Atomoxetine is a non-stimulant drug used in the treatment of ADHD. Case Presentation: In this article, a case of obsessive-compulsive disorder (OCD) which occurred in an 11-year-old boy with an increased dose of atomoxetin...

Background: External beam radiation therapy is often administered to patients implanted with silicone gel breast prosthesis. The aim of this study was to investigate the influence of silicone gel breast prosthesis on photon dose distributions. In the event of recurrence, the oncologist may be forced to irradiate through the prosthetic device. To quantify the dose enhancement or reduction below ...

background: natural background radiation of a particular region is one of the distinctive factors defining the status of environment. eloor island is an industrial area in ernakulum district of the state of kerala, india. the indoor and outdoor gamma level measurements have been carried out for the region for evaluating the annual effective dose to the population residing in this area. material...

abstract introduction:  this study was performed to compare the effects of low-dose interferon beta-1(cinnovex,30 mcg) and high-dose interferon beta-1(rebif,44 mcg) on the reduction of the number and size of plaques in magnetic resonance imaging (mri) in patients with multiple sclerosis (ms). methods and materials: this historical cohort study, which was performed in 2014 in sanandaj (western p...

Background: Calcineurin inhibitors (CNI) have significantly reduced the incidence of acute rejection. Nephrotoxicity however may contribute to long-term allograft dysfunction. Mycophenolate mofetil (MMF) may allow cyclosporine (CsA) dose reduction without increasing the risk of rejection. Methods: In seventy-eight living unrelated kidney transplant patients with renal dysfunction, we studi...