The abuse of Acetaminophen (over-the-counter drug) is rapidly increasing globally, thus inducing physiological alterations and toxicity. In this study, it was hypothesized that overdose acetaminophen may induce certain type anemia; hence the anemia induced by oral exposure to toxic dose evaluated. Fifteen (15) Wistar rats weighing approximately 160 g were grouped into three (3) groups; Group 1 ...

BACKGROUND Most studies on blood donors are centered on the selective evaluation of red blood cell parameters with little or no regard to white blood cells and platelets. METHODS One hundred and twelve male blood donors comprising 43 first-time and 69 regular blood donors, drawn from a tertiary health facility in the Niger Delta of Nigeria, participated in the study. Their hematological param...

Abbreviations: OTA: Ochratoxin-A; hr: Hour; ppm: Parts-Per Million; b.wt.: Body Weight; RBC: Red Blood Cell; Hb: Hemoglobin; PCV: Packed Cell Volume; TLC: Total Leukocyte Count; DLC: Differential Leukocyte Count; MCV: Mean Corpuscular Volume; MCH: Mean Corpuscular Hemoglobin; MCHC: Mean Corpuscular Hemoglobin Concentration; BUN: Blood Urea Nitrogen; ALP: Alkaline Phosphatase; ALT: Alanine Trans...

Sickle cell disease is one of the most common hemoglobinopathy worldwide. It an autosomal recessive genetic disorder caused by replacement adenine to thymine nucleotide in beta chain hemoglobin results valine for glutamic acid at 6th position. This substitution formation sickle (HbS) which turn leads a reduced lifespan red blood cells (RBC). In hypoxic conditions, HbS has tendency aggregate and...

Horse blood has a higher tendency to form red blood cell (RBC) aggregates compared with human blood, with this enhanced aggregation previously attributed to differences in plasma factors. Our results confirm this observation and further indicate that washed horse RBC also have a significantly higher aggregation tendency in dextran 70 solutions (i.e., horse RBC have a higher "aggregability"). In...

It was demonstrated in this study that the mean values of the different red blood cell count and white blood cell parameters showed significant changes during gestation. RBC, PCV and Hb increased while total WBC and segmented neutrophils increased after the second gestation period in the second period. The numbers of total leucocytes and segmented neutrophils increased after the second period.

Red blood cell (RBC) deformation is a dominant factor in the rheological properties of blood in vessels smaller than 300 micrometers. A reduction in cell deformability is associated with health conditions such as malaria and diabetes. The extensional flow within a microfluidic cross-slot microchannel has been proposed as a mechanism for measuring the deformation of cells. Three-dimensional simu...

Mesoporous silica nanoparticles (MSNs), with their large surface area and tunable pore sizes, have been widely applied for anticancer therapeutic cargos delivery with a high loading capacity. However, easy aggregation in saline buffers and limited blood circulation lifetime hinder their delivery efficiency and the anticancer efficacy. Here, new multifunctional MSNs-supported red-blood-cell (RBC...

background: red blood cell and other blood products play a crucial role in management of different disease processes, but in spite of implementation of crucial steps to improve the process of request for blood and blood consumption, there is still not enough information available regarding the proper practice in many medical centres. we aimed to evaluate the status of blood product requests and...

Herein we describe an assay that was developed to quantitate the binding of normal red blood cells (RBC), labeled with carboxy fluorescein diacetate (C-FDA), to rosetting Plasmodium falciparum-infected RBC. The binding of RBC obtained from various animal species or humans to different strains or clones of rosetting P. falciparum-infected RBC was studied. A strain-specific preference of rosettin...