Cantharidin, a vesicant agent, and asiaticoside, which promotes the healing of skin ulcers, were tested for carcinogenicity by topical applications to the skin of hairless mice. A short-term tetrazolium test indicated that both compounds were weak carcinogens. The compounds were then separately painted twice weekly on the dorsal skin up to about 20 months; some of the mice had previously been i...

Pralatrexate is a novel antifolate, which shows increased antitumor activity in human tumor xenograft studies in mice compared with methotrexate. We investigated the effects of pralatrexate in a patient with adult T-cell lymphoma/leukemia with significant skin involvement. Atypical lymphocytes in epidermal Pautrier microabscesses were positive for HTLV-1. After the patient presented with leukem...

background: in the current study the effect of shielded colpostat on rectum received dose was calculated in cervical brachytherapy using monte carlo (mc) method. materials and methods: two 60co sources of gzp6 brachytherapy unit used for intracavitary treatments were simulated using mcnpx monte carlo code. also the two types of colpostats including shielded and unshielded were simulated inside ...

Skin immunization is effective against a number of infectious diseases, including smallpox and tuberculosis, but is difficult to administer. Here, we assessed the use of an easy-to-administer microneedle (MN) patch for skin vaccination using an inactivated rotavirus vaccine (IRV) in mice. Female inbred BALB/c mice in groups of six were immunized once in the skin using MN coated with 5 μg or 0.5...

BACKGROUND The potential of S-1 for the treatment of metastatic renal cell carcinoma (mRCC) has been shown in two phase II studies. We aimed to assess the safety, tolerance, pharmacokinetics and clinical activity of S-1 combined with sorafenib in patients with mRCC. PATIENTS AND METHODS In this multicenter, single-arm, open-label, phase I/II study of S-1 plus sorafenib, we recruited patients ...

Background: During interventional cardiology processes, patients especially women and children receive high radiation doses due to their sensitivity.Objective: In this study, we evaluated a pediatric patient dose separately in those undergone intervention cardiac procedure. Material and Methods: In this cross sectional study, a public hospital with 252 patients, Entrance Skin Dose (...

Introduction: Accelerated Partial Breast Irradiation (APBI) is an effective treatment for breast carcinomas because of its limited number of fractions. Strut-adjusted volume implant (SAVI) is a HDR brachytherapy applicator to deliver the prescription dose with good PTV coverage and acceptable dose to skin, chest wall and organ at risks. Acceptable clinical outcomes depend on a...

Background: Although ionizing radiation is widely used to diagnose many diseases, the relevant hazards are known to be as an important limitation of its application. It is believed that the awareness of ionizing radiation dose values is one of the main stages in patient's radiation protection. The purpose of this study has been to investigate the level of physicians' knowledge about radiation d...