Objective To determine seroprotection and vaccine response rates produced by a diphtheria–tetanus–acellular pertussis–inactivated poliovirus–Haemophilus influenzae type-b conjugate (DTaP–IPV//PRP~T) vaccine containing a polyribosyl-ribitol-phosphate (PRP)– tetanus toxoid conjugate (PentaximTM) and given with a hepatitis B vaccine. Methods In this multicentre open-label trial, 424 infants who re...

Vaccines are the cornerstone of infectious disease control and prevention. The outbreak SARS-CoV-2 has confirmed urgent need for a new approach to design novel vaccines. Plant viruses their derivatives being used increasingly development medical biotechnological applications, this is reflected in number preclinical clinical studies. have unique combination features (biosafety, low reactogenicit...

Background: Patients with autoimmune disease often require immunosuppressive medications that may increase their risk of developing severe illness from COVID-19. The importance immunization in this population is particularly high. While the studied vaccines show efficacy general population, nothing known regarding immune response or safety profile patients and those taking immunomodulatory medi...