Fast migrating cerebrosides (FMC) are derivatives of galactosylceramide (GalCer). The structures of the most hydrophobic FMC-5, FMC-6, and FMC-7 were determined by electrospray ionization linear ion-trap mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy complementing previous NMR spectroscopy and gas chromatography-mass spectrometry to be 3-O-acetyl-sphingosine-GalCer der...

OBJECTIVE To evaluate serum interferon-α (IFNα) activity in the context of autoantibody profiles in patients with juvenile dermatomyositis (JDM). METHODS Sera from 36 patients with JDM were analyzed. Autoantibody profiles were determined by probing microarrays, which were fabricated with ∼80 distinct autoantigens, with serum and a Cy3-conjugated secondary antibody. Arrays were scanned and ana...

reactivity (AHR), because of inherent problems with using a pharmacologic agent in epidemiologic surveys. To our knowledge, no studies exist that compare MIC with EVH in known asthmatics. We conducted a prospective, randomized, crossover trial with a group of subjects (n = 16) who met the American Thoracic Society definition of asthma with these objectives: (1) to compare the sensitivity of EVH...

The present article summarizes the development and testing of a reactivity modulation device developed by French Atomic Alternative Energies Commission (CEA). It was installed in CROCUS reactor Swiss Federal Institute Technology Lausanne (EPFL). Experimental tests were performed framework collaboration between CEA EPFL. so-called PISTIL aims at measuring nuclear transfer function frequency rang...

T-cell identity is established by the expression of a clonotypic T-cell receptor (TCR), generated by somatic rearrangement of TCRα and β genes. The properties of the TCR determine both the degree of self-reactivity and the repertoire of antigens that can be recognized. For CD8 T cells, the relationship between TCR identity-hence reactivity to self-and effector function(s) remains to be fully un...

The present paper focuses on the modeling of CROCUS reactor with French MORET 5 continuous energy code and compares keff, anti-reactivity effects (variation keff normalized to due insertion an absorber), sensitivity coefficients kinetics parameters those provided by other reference codes. aim is mainly extend experimental validation/verification database use physics applications. A suite about ...

In this work, we evaluate the impact of simulating thermal-hydraulics feedback in criticality risk assessment a benchmark configuration corresponding to simplified debris bed. We have recently discussed coupling multi-phase code MC3D with reactivity evaluation scheme based on multi-point kinetics, which paves way towards system behavior terms energy release. analyze as function state system. Fo...