Mitochondria are the major effectors of cardioprotection by procedures that open the mitochondrial ATP-sensitive potassium channel (mitoKATP), including ischemic and pharmacological preconditioning. MitoKATP opening leads to increased reactive oxygen species (ROS), which then activate a mitoKATP-associated PKCε, which phosphorylates mitoKATP and leaves it in a persistent open state (Costa AD, G...

Mesoporous Materials In article number 2208316, Xiaohui Ju and co-workers report the design of free-blockage reactive oxygen species (ROS)-responsive mesoporous silica nanoparticles (MSNs) as potential drug delivery systems. Methyl sulfide units are functionalized onto MSNs through co-condensation or grafting pathways. an ROS-rich environment, nanocarriers undergo structure polarity changes rel...

A major cause of male infertility, which includes 50 causes of infertility, is oxidative stress.  The aerobic respiration in the sperm cell is associated with the production of reactive oxygen species (ROS). Some reactions such as sperm capacitation and acrosome reactions require moderate levels of ROS. However, when the amount of ROS production surpasses the natural antioxidant defense of the ...