Reactive oxygen species (ROS) are involved in cell signaling, aging, and death and play a role in carcinogenesis. However, whether ROS are bystanders or active effectors of apoptosis was unclear until recently. New evidence shows that the killer lymphocyte protease granzyme B activates a conserved biochemical pathway centered on respiratory chain disruption to trigger mitocentric ROS-dependent ...

This immunological study of 40 patients with frozen shoulder showed a pretreatment increase in immune complex levels, C-reactive protein, and decreased lymphocyte transformation to phytohemagglutinin and concanavalin A compared to a control group. Repeat estimations after 8 months showed that values tended to approach control levels.

OBJECTIVES To estimate the extent of genomic DNA damage and killing of lymphocytes by reactive oxygen intermediates in autoimmune diseases. METHODS 8-Oxo-7-hydrodeoxyguanosine (8-oxodG), a promutagenic DNA lesion induced by reactive oxygen intermediates, was measured by high performance liquid chromatography, coupled with electrochemical detection, in hydrolysates of DNA which had been extrac...

background: an increase in the number of intraepithelial lymphocytes (iel) in the duodenal mucosa is an important criterion for the histological diagnosis of celiac disease (cd). we determined the normal range for intraepithelial lymphocytes (iel) in the second part of duodenum in healthy iranian population. materials and methods: four biopsy samples of the endoscopically normal appearing mucos...

Objective: In addition to causing immunosuppression, hemodialysis may increase the risk of infection, given that patients are more frequently exposed vascular interventions and operative procedures. The present study aims reveal prevalence spondylodiscitis in on hemodialysis, potential factors, parameters help early diagnosis disease. Materials Methods: Patients who received treatment unit betw...

In this nested case-control study, we evaluated haematological and morphological parameters of hospitalised patients with real-time polymerase chain reaction verified COVID-19 infection compared to similar symptomatology but without infection. Seventy-four positive 228 negative were routine parameters. Severe disease was defined as death and/or need intensive care treatment. Twenty-seven 18 fur...

The [3H]thymidine uptake procedure for measuring lymphocyte responses was applied to lymphocytes derived concurrently from synovial effusions and from peripheral blood. The stimulating antigens were crude preparations of those micro-organisms that are related to the enteritis and the non-gonococcal urethritis that precipitate reactive arthritis. Salmonella, shigella, and campylobacter antigens ...