Microwave-assisted organic synthesis is an enabling technology for accelerating drug discovery and development processes. Microwave organic synthesis opens up new opportunities to the synthetic chemist in the form of new reaction that are not possible by conventional heating and serve a flexible platform for chemical reaction. This review focuses on the advances in the developing of innovative ...

An overview of the discovery of reaction intermediates and associated concepts in physical organic chemistry is presented. Particular attention is paid to chronology of ideas, frequency of occurrence of reaction intermediates in the library of organic reactions used in organic synthesis, and the lexicon of scientific terms used in the language of physical organic chemistry. General logic decisi...

The copper(I)-catalyzed 1,3-dipolar cycloaddition between alkynes and azides (click chemistry) to form 1,2,3-triazoles is the most popular reaction due to its reliability, specificity, and biocompatibility. This reaction has the potential to shorten procedures, and render more efficient lead identification and optimization procedures in medicinal chemistry, which is a powerful modular synthetic...

Channel-fouling is a pervasive problem in continuous flow chemistry, causing poor product control and reactor failure. Droplet chemistry, in which the reaction mixture flows as discrete droplets inside an immiscible carrier liquid, prevents fouling by isolating the reaction from the channel walls. Unfortunately, the difficulty of controllably adding new reagents to an existing droplet stream ha...

Predicting the course and major products of arbitrary reactions is a fundamental problem in chemistry, one that chemists must address in a variety of tasks ranging from synthesis design to reaction discovery. Described here is an expert system to predict organic chemical reactions based on a knowledge base of over 1500 manually composed reaction transformation rules. Novel rule extensions are i...

Multielectron redox chemistry involving small molecules such as O2, H2O, N2, CO2, and CH4 is intrinsic to the chemical challenges surrounding sustainable, low-carbon energy generation and exploitation. Compounds with more than one metal reaction site facilitate this chemistry by providing both unique binding environments and combined redox equivalents. However, controlling the aggregation of me...

Kinetics of the reaction of the heaviest hydrogen atom with H2, the 4Heμ + H2 → 4HeμH + H reaction: Experiments, accurate quantal calculations, and variational transition state theory, including kinetic isotope effects for a factor of 36.1 in isotopic mass Donald G. Fleming,1,a) Donald J. Arseneau,1 Oleksandr Sukhorukov,1,b) Jess H. Brewer,2 Steven L. Mielke,3 Donald G. Truhlar,3,a) George C. S...

nanomagnetite-fe3o4 is used as a highly efficient, mild, green and recyclable nanomagnetite catalyst for the synthesis of 4,4´-(arylmethylene)-bis(3-methyl-1-phenyl-1h-pyrazol-5-ol) derivatives in solvent-free conditions. the condensation reaction of 3-methyl-1-phenyl-1h-pyrazol-5(4h)-one with aromatic aldehydes affords the title compounds in high yields and short reaction times. the nanocataly...

Mineral assemblages, reaction textures and mineral composition of the metapelitic rocks from the Mahneshan area in NW Iran are studied to reconstruct the reaction history of the rocks. The phase relation on the real mineral chemistry AFM, AFMn compatibility diagrams and mineral isograds in chloritoid-free and chloritoid-bearing metapelites of Mahneshan Complex were studied in order to determine...

An organosuperbase (N,N-dimethylbiguanide) immobilized on mesoporous and magnetically separable silica supports, was found for the first time, to act as a highly-stable, scalable and efficient heterogeneous catalyst for the Henry reaction under mild and neutral condition. Several factors such as catalyst amount, solvent and reaction time concerning the reactivity were also discussed. The proced...