The tumor suppressor Retinoblastoma (Rb) protein is highly phosphorylated in cancer cells largely due to the overexpression of cyclins or the loss of expression of cyclin dependent kinase inhibitors (cdki). Hyperphosphorylation of Rb promotes proliferation, and plays a role in the regulation of apoptosis. Recently, inhibition of cyclin dependent activity toward Rb has been identified as a strat...

The involvement of the retinoblastoma gene product (Rb) and its family members (p107 and p130) in cell cycle exit and terminal differentiation of neural precursor cells has been demonstrated in vitro. To investigate the roles of Rb and p107 in growth, differentiation and apoptosis in the developing and mature cerebellum, we selectively inactivated either Rb alone or in combination with p107 in ...

Chinese script encodes phonology less transparently than alphabetic writing systems, but provides more clues to meaning. We propose that amount of activation depends on encoding transparency, a plausible theoretical statement which has received mixed support using standard priming tasks. The repetition blindness (RB) paradigm was employed to infer activation during reading of Chinese vs. Englis...

The RB protein family (RB, p107, and p130) has overlapping and compensatory functions in cell-cycle control. However, cancer-associated mutations are almost exclusively found in RB, implying that RB has a nonredundant role in tumor suppression. We demonstrate that RB preferentially associates with E2F target genes involved in DNA replication and is uniquely required to repress these genes durin...

In this paper, a new structure for buck-boost Z-source converter based on Z-H topology is proposed. The proposed converter consists of two LC networks similar to the conventional Z-source and Z-H converters. One of the characteristics of the proposed structure is that, without any changing in its’ power circuit, it can be used in different conversions such as dc/dc, dc/ac and ac/ac. This unique...

− In this paper, small signal characteristic of a LLC resonant converter is analyzed. LLC resonant converter was been reported in many papers recently because of its simple structure, high efficiency and high switching frequency capability. In order to make practical use of this topology, understanding its small signal characteristic is essential to design the control loop. For PWM converter, s...

With the development of power electronics devices, resonant converter is proved to be more efficient than conventional converter as it employs soft switching technique. Among the three basic configuration of resonant converter, Series Resonant Converter (SRC), Parallel Resonant Converter (PRC) and Series Parallel Resonant Converter (SPRC), the LLC configuration under SPRC is proved to be most e...

Rose Bengal (RB) is a potential photosuturing agent that may improve standard dermatologic surgical closure techniques. However, RB produces reactive oxygen species with photoactivation and its photomutagenic potential must be considered in clinical application. We investigated cytotoxicity, mutagenicity, and singlet oxygen (SO) production of RB on epithelial Chinese hamster ovary cell line. Ce...

The product of the retinoblastoma (Rb) gene can form complexes with the transforming proteins of small DNA tumor viruses, including SV40 large T antigen (Tag), adenovirus E1A, and the human papilloma virus E7. The strong correlation between their ability to transform and their ability to bind Rb protein suggests that these oncoproteins exert their effect through blocking the Rb function. SV40 T...

In the current study, reduction of nitrogen oxide from exhaust gas in the presence of NH3 as reductant on selective catalytic reductant (SCR) impregnated catalytic converter was simulated using Comsol© software. Mass transfer (one-dimensional) and heat transfer (three-dimensional) governing equations were taken into account to model the unsteady state behavior of the catalytic converter. Modeli...