Orlistat (Xenical) (Fig. 1), a highly lipophilic tetrahydro derivative of lipstatin, is an inhibitor of gastric and pancreatic lipases required for the hydrolysis of dietary fat (triacylglycerols) in the gastrointestinal tract into free fatty acids and monoacylglycerols. A major contributing factor to the development and maintenance of obesity is excessive intake of dietary triglycerides. Inhib...

A new integer sequence defined on the basis of the EP numbers is introduced (A117570). The EP numbers are defined as ( ) ( )( ) Q P C B A Q Pb Cb Bb Ab x EP n n n + + + + + + + + + + = − − L L 2 1 , where , e non-negative integers and b is the base. We illustrate some general characteristics of EP numbers and the EP sequence. We observe the existence of pairs of consecutive EP numbers (twin EP ...

Comment on: Macurek L, et al. Cell Cycle 2013; 12:251-62.

[This corrects the article on p. 251 in vol. 21, PMID: 26618031.].

Comment on: Macurek L, et al. Cell Cycle 2012; 12:251-62.