background and aims: portulaca oleracea (purslane) herb has renewed an interest in medicinal plants because its aerial parts usage generally does not elicit any side effects. in the present study, we aimed to evaluate the anti-diabetic effect of hydro-ethanolic extract of p. oleracea seeds in alloxan- induced diabetic rats. materials and methods: in the test group, diabetic rats received hydroe...

treatment with amiodarone, a commonly prescribed antidysrhythmic agent, is associated with pulmonary fibrosis (pf) which is a commonly progressive and untreatable dieases. caffeic acid phenethyl ester (cape) is a phenolic antioxidant and an active anti-inflammatory, anticancer, antimicrobial and antioxidant component of propolis (bee glue; a resinous hive product collected by honey bees). in th...

objective(s) the aim of this study was to investigate glycoconjugates distribution patterns as well as their changes during the course of pituitary portal vasculogenesis and angiogenesis. materials and methods formalin fixed paraffin sections of 10 to 20 days of sprague dawly rat fetuses were processed for histochemical studies using four different horseradish peroxidase (hrp) conjugated lectin...

introduction: tamoxifen is a nonstroidal antiestrogen prescribed for treatment of breast cancer. the aim of this study was to investigate the effect of tamoxifen on testosterone level in the serum and sperm count in the epididymis of adult male wistar rats. methods: three groups of rats received 200, 400 and 600 µg/kg body weight tamoxifen dissolved in solvent (60% ethanol in physiological solu...

introduction: different modalities have been used to achieve better results in wound healing among which are laser and pharmacological agents. to our knowledge, there is no investigation to compare phenytoin and laser together. in this study, we aimed to evaluate laser and phenytoin efficacy and compare their effect on wound healing. methods: we used 60 rats. the animals were divided into 4 gro...

the objective of this study was to evaluate several drug combinations for intraperitoneal anaesthesia in laboratory rats. following dose determination of anaesthetics in a pilot study, 45 healthy adult male rats were randomly assigned in 9 treatment groups and received propofol (alone or in combination with xylazine, midazolam, or ketamine) or ketamine (in combination with xylazine, midazolam, ...

introduction: cisplatin is used as a chemotherapeutic agent for the treatment of human ovarian and testicular cancers. this study was designed to investigate the protective role of taurine against cisplatin-induced kidney injury. methods: male wistar rats were divided into 4 groups (n=8) (1) saline-treated group (2) cisplatin-treated group (10 mg/kg, i.p.), (3) group that received taurine (200 ...

background: recently, there are increasing concerns and interests about the potential effects of electromagnetic field (emf) on both human and animal health. objective: the goal of this study was to evaluate the harmful effects of 50 hz non-ionizing emf on rat oocytes. materials and methods: in this experimental study 30 rats were randomly taken from laboratory animals and their ags and weights...

simultaneous exposure of highly-used chemical and physical agents are expected to happen in many occupations. in the present study the impact of simultaneous exposure to noise and formaldehyde on oxidative stress in blood and liver tissue of rat was investigated. animal study was conducted in the school of public health, shahid beheshti university of medical scineces, tehran, iran in 2013. a to...