Supervising Section Editor: Sean O. Henderson, MD Submission history: Submitted July 1, 2013; Accepted July 15, 2013 Electronically published October 9, 2013 Full text available through open access at http://escholarship.org/uc/uciem_westjem DOI: 10.5811/westjem.2013.7.18845 [West J Emerg Med. 2013;14(6):645.] David Geffen School of Medicine, University of California Los Angeles, Department of ...

Several trials show a relationship between skin toxicity, response rate, and overall survival in cetuximab-treated patients. We analyzed our database to evaluate the importance of skin rash as a surrogate marker of favorable outcome in cancer patients referred to our institution in the last three years. We retrospectively analyzed 90 cetuximab-treated patients: 57 colon cancer patients, 10 NSCL...

BACKGROUND Skin toxicity is a common adverse effect of erlotinib and other anti-epidermal growth factor receptor (EGFR) agents. The aim of the study was to explore the relationship between markers in the EGFR pathway and skin rash. PATIENTS AND METHODS Eighteen patients with metastatic breast cancer were treated with daily oral erlotinib at 150 mg. Skin biopsies were obtained at baseline and ...

BACKGROUND Lenalidomide is approved for treating transfusion-dependent anemia due to lower-risk del(5q) myelodysplastic syndromes (MDS). In clinical trials, rash was common, although severe rash was infrequent. To examine rash in patients with MDS treated with lenalidomide in the real world, the Celgene Global Drug Safety database was analyzed and compared with clinical trials. MATERIALS AND ...

OBJECTIVE Epidermal growth factor receptor inhibitors can result in a severe rash in 5-10% of patients and can detract from quality of life. The objective of this study was to identify clinical predictors of severe rash in the hope of utilizing such factors in the design of future rash palliative and prevention trials. METHODS 933 cetuximab-treated patients enrolled on N0147, an adjuvant chem...

The risk to the fetus from primary rubella occurring in the first trimester of pregnancy is considerable.' Despite the immunisation programme about 20 to 60 cases a year of congenital rubella are reported in the United Kingdom.2 We report on a case which illustrates the unfortunate consequences of failing to consider the possibility of rubella in a patient presenting with a rash in early pregna...

To cite: Ranpara MP, Yesudian PD. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2015211792 DESCRIPTION A 69-year-old woman presented to the emergency department with a painful rash of 5 weeks duration. The rash started as two discrete erythematous plaques on the left medial malleolus and was treated as cellulitis by her general practitioner. Despite antibiotic t...

Methods We report a case of drug rash induced by levothyroxine and currently oral desensitization. A 31 year-old woman had been diagnosed as Hashimoto’s Thyroiditis. She was having levothyroxine for 9 years when she begun to present bilateral eyelids maculopapular rash. Blood exams and physical examination were normal except for the eyelids ́ rash. As she stopped using levothyroxine, the rash ha...

Cutaneous manifestations are uncommon with malaria. These include urticaria, purpura fulminans, and petechial rash. We report on a series of three patients from a single family who had an urticarial rash with fever that was subsequently diagnosed to be caused by malaria. Urticarial rash has been previously reported with both falciparum and vivax malaria infections. Although the exact pathogenes...

PURPOSE This study evaluated the incidence of imatinib-associated skin rash, the interventional outcomes of severe rash, and impact of severe rash on the outcomes of imatinib treatment in gastrointestinal stromal tumor (GIST) patients. MATERIALS AND METHODS A total of 620 patients were administered adjuvant or palliative imatinib for GIST at Asan Medical Center between January 2000 and July 2...