نتایج جستجو برای: ras al
تعداد نتایج: 471474 فیلتر نتایج به سال:
Inhibitors that target the receptor tyrosine kinase (RTK)/Ras/mitogen-activated protein kinase (MAPK) pathway have led to clinical responses in lung and other cancers, but some patients fail to respond and in those that do resistance inevitably occurs (Balak et al., 2006; Kosaka et al., 2006; Rudin et al., 2013; Wagle et al., 2011). To understand intrinsic and acquired resistance to inhibition ...
We read with interest the review article by Mackay and Twelves (2003) on the efficacy of protein kinase C (PKC) inhibition in cancer treatment and we wish to comment on it. As highlighted by the authors, although PKC involvement in tumorigenesis is an old notion, contradictory findings are reported in the literature concerning the effects of PKC on cell invasivity, growth and apoptosis. That ca...
It is now well recognized that in the vast majority of tumor types, for the approach of "kinase inhibition" to exhibit a significant effect, whether the data are from an in vitro assay, an animal model or the clinic, requires that multiple complementary kinases be simultaneously inhibited. This combined inhibition is not only kill the tumor cell but also to suppress and kill tumor cells that se...
In this paper we introduce the SpeakCorrect system which is a Computer Aided Pronunciation Training (CAPT) system for native Arabic students of English. The system is designed with optimized performance for the target users group. It is L1 dependent system and only the frequent pronunciation errors of native Arabic speakers are examined. Several adaptation techniques such as Speaker Adaptive Tr...
Mestastatic prostate cancer cells (MPCCs) frequently metastasize to bone, which is a “favorite soil” for colonization and proliferation of MPCCs. Prostate cancer bone mestastasis is tightly associated with tumor-induced bone lesions, most commonly caused from the etiological imbalance between osteoblastic bone formation and osteoclastic bone resorption, and from the anti-tumor immune response. ...
1. Thum T, et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signaling in fibroblasts. Nature. 2008;456(7224):980–984. 2. Patrick DM, et al. Stress-dependent cardiac remodeling occurs in the absence of miR-21 in mice. J Clin Invest. 2010;120(11):3912–3916. 3. Hatley ME, et al. Modulation of K-Ras-dependent lung tumorigenesis by microRNA-21. Cancer Cell. 2010;18(3):2...
statement of problem: recurrent aphthous stomatitis (ras) is one of the most common inflammatory diseases encountered in dental practice, but the precise etiology and pathogenesis of the disease is not fully understood. vascular endothelial growth factor (vegf) is a multifunctional angiogenic cytokine involved in angiogenesis and wound healing. there is evidence that vegf could play an importan...
Communicative moves and lexical cohesion patterns (LCPs), as mounting evidence shows, are two important indicators in writing and publishing the RAs. However, the interaction between these two crucial elements and the contribution of this interaction to the failure or success of the RAs have not been given due attention to date. Having this in mind and based on a sound theoretical framework, at...
Recurrent aphtus stomatitis (RAS) is an oral mucous lesion in patients with no other signs of disease. Investigators have always notified the role of immune system especially humoral immunity in aphtus immunopathogenesis. The aim of this case-controlled study was to measure amount of serum immonogiobulins (A,G,M) and complement component (C3 C4) in patients with RAS and to evaluate any relation...
There are very few studies about K-ras mutations in colorectal cancer (CRC) from developing countries such as Iran. It is therefore essential to conduct studies to learn about the molecular signature of such tumors, allowing the determination of an appropriate management plan. In the present study, we aimed to determine the frequency and types of K-ras mutations among patients with CRC in Iran....
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