OBJECTIVE The transradial catheterization (TRC) is becoming widespread, primarily for neurointerventions. Therefore, the evaluation of radial artery puncture in clinical practice and a better understanding of the anatomy are important to improve the safety of neuroendovascular surgery. METHODS Ten formalin-fixed adult Korean cadavers were dissected to expose radial artery (RA), brachial arter...

Immune cell infiltration of the kidney is a constant feature in salt-sensitive hypertension (SSHTN). We evaluated the relationship between the renal inflammation and pressure natriuresis in the model of SSHTN that results from transient oral administration of N(ω)-nitro-L-arginine methyl ester (L-NAME). Pressure natriuresis was determined in Wistar rats that received 4 wk of a high-salt (4% NaC...

There is an appetite to improve the reproducibility of quantitative analysis undertaken across government. Our team supports conversion regular publications into Reproducible Analytical Pipelines (RAP). To achieve this, we developed a roadmap work with analysts in our organisation and help them transform their pipelines build skills.
 An audit current RAP status all assisted resource alloc...

The methylmalonyl coenzyme A (methylmalonyl-CoA)-specific acyltransferase (AT) domains of modules 1 and 2 of the 6-deoxyerythronolide B synthase (DEBS1) of Saccharopolyspora erythraea ER720 were replaced with three heterologous AT domains that are believed, based on sequence comparisons, to be specific for malonyl-CoA. The three substituted AT domains were "Hyg" AT2 from module 2 of a type I po...

INTRODUCTION The current mainstay of the treatment of thrombotic antiphospholipid syndrome (APS) is long-term anticoagulation with vitamin K antagonists (VKAs) such as warfarin. Non-VKA oral anticoagulants (NOACs), which include rivaroxaban, have been shown to be effective and safe compared with warfarin for the treatment of venous thromboembolism (VTE) in major phase III prospective, randomize...

A pandemia causada pela Covid-19 tem afetado negativamente a Saúde Mental de profissionais saúde, especialmente os que trabalham na linha frente assistencial, pois lidam diariamente com o medo se infectarem e outros, carência equipamentos proteção individual sobrecarga trabalho. Este texto objetiva discutir as nuances relacionadas à dos saúde do Brasil em tempos por Covid-19. Elenca importância...