We show that cell lines derived from childhood alveolar rhabdomyosarcoma (RMS) are very sensitive to the growth-inhibitory effects of the immunosuppressive agent rapamycin (RAP), compared to other human cell lines (50% inhibitory concentration range of 0.1-8 ng/mi, compared to 1280 to >10,000 ng/ml). Our data suggest that the sensitivity of RMS lines is due to RAP inhibition of insulin-like gro...

Constituído de letra e canção, o rap é um gênero musical afro-diaspórico que mobiliza engaja diversos sujeitos por meio da cultura periférica. A “nova condição do rap” enquanto uma categoria análise nos ajuda a compreender novas características deste musical, possibilitou refletir sobre possível religiosa” rap. Dessa forma, este artigo tem como objetivo 1) os “modos mítico-poéticos” brasileiro ...

Rap is a member of the Ras family of small GTPases. Mammalian Rap proteins regulate many biological processes including cell and matrix adhesion, migration, proliferation, cytoskeletal dynamics, cell polarity and secretion. Rap1 is activated by TSH and cAMP in thyroid cells independently of PKA. TSH regulates differentiated gene expression and proliferation. Many of these effects are mediated t...

ii To my family, friends and professors who helped me throughout this experience iii ACKNOWLEDGEMENTS This research project was made possible with the help of many supporting people throughout the process. I wish to express my gratitude firstly to my supervising professor, Dr. Hosin " David " Lee for the support and advice needed to start and finish this project. I would also like to thank the ...

OBJECTIVES To correlate clinical and histopathologic features of an eye with retinal angiomatous proliferation (RAP) secondary to age-related macular degeneration and to investigate the expression of von Willebrand factor (VWF) and vascular endothelial growth factor (VEGF) in this condition. METHODS Histopathologic features from serial sections through the globe of an 87-year-old woman with R...

We have measured the concentration of cartilage-derived retinoic-acid-sensitive protein (CD-RAP) in synovial fluid (SF) from the knees of 49 patients with osteoarthritis (OA) and 79 with rheumatoid arthritis (RA) in order to investigate the correlation between the type of joint disease and level of CD-RAP. The mean concentration of CD-RAP in synovial fluid was significantly higher in OA than in...

Right atrial pressure (RAP) may become substantially elevated during heart failure and has been reported to reduce collateral flow to the ischemic myocardium of isolated hearts. The effect of elevated RAP on blood flow to collateral-dependent and normal myocardium of in situ hearts was studied in 20 open-chest anesthetized dogs with acute occlusion of the left anterior descending coronary arter...

We show that cell lines derived from childhood alveolar rhabdomyosarcoma (RMS) are very sensitive to the growth-inhibitory effects of the immunosuppressive agent rapamycin (RAP), compared to other human cell lines (50% inhibitory concentration range of 0.1-8 ng/ml, compared to 1280 to > 10,000 ng/ml). Our data suggest that the sensitivity of RMS lines is due to RAP inhibition of insulin-like gr...

Many applications of virtual agents, including those in healthcare and education, require engaging users in dozens or hundreds of interactions over long periods of time. In this effort, we are developing conversational agents to engage young adults in longitudinal lifestyle health behavior change interventions. Hip-hop and rap are one of the most popular genres of music among our stakeholders, ...

Reclaimed asphalt pavement (RAP) arises from the demolition of road layers. The Optimal Recycling Asphalt Pavements Project concerns cold recycling 100 % RAP without binder addition in base and subbase layers low-traffic roads. In this context, a test program was performed with Rhine region materials to evaluate impact mastic coating untreated RAP. A source reclaimed asphalts 4.4 bitumen is tes...