CONTEXT Grading scientific evidence is a critical step in developing practice guidelines and quality performance measures. GENERAL QUESTION What is the most useful way to grade evidence? SPECIFIC QUESTION How should we grade the recommended clinical practices for patients with diabetes? STANDARD APPROACH Hierarchical grading systems (e.g., grades I, II, and III), such as that used by the ...

BACKGROUND Patients with proliferative lupus nephritis are at risk of frequent relapses. Whether low- dose prednisone prevents relapses is uncertain. OBJECTIVES We undertook a pilot RCT to determine the feasibility of a larger trial. DESIGN Pilot randomized controlled trial. SETTING Single center Canadian outpatient nephrology clinic. PATIENTS Participants with systemic lupus erythemato...

With the growing interest in using real-world evidence (RWE) for regulatory purposes, researchers and policy makers are considering how best to assess credibility of RWE. Because randomized controlled trial (RCT) has long been regarded as gold standard high-quality research, one approach being pursued is see what extent findings from RCTs can be replicated based on analyses nonrandomized data (...

BACKGROUND AND PURPOSE Autologous conditioned serum (ACS) is a disease-modifying drug for treatment of knee osteoarthritis, and modest superiority over placebo was reported in an earlier randomized controlled trial (RCT). We hypothesized that when given the opportunity, placebo-treated patients from that RCT would now opt for ACS treatment, which would result in a greater clinical improvement t...

Objective: To evaluate the effectiveness of intralesional bleomycin in comparison to cryotherapy treatment cutaneous warts. Method: The randomized controlled trial was conducted at Department Dermatology, Jinnah Postgraduate Medical Centre, Karachi, from January July 2021, and comprised patients either gender aged 18-60 years who had warts for 1-48 weeks. subjects were divided into group A trea...

objective: some of the adverse effects of aspirin including peptic ulcers, gastrointestinal bleeding and aspirin resistance compelled researchers to find a suitable alternative with fewer adverse effects. in this clinical trial, we aimed to find the effective antiplatelet dose of garlic. materials and methods: this randomized controlled clinical trial (rct) was conducted on 62 healthy volunteer...

BACKGROUND The effectiveness of an intervention in clinical practice is often reduced compared to the efficacy demonstrated in a randomised controlled trial (RCT). In this comparative effectiveness study, the RCT-proven efficacy of a diabetes education programme for type 1 diabetic patients (PRIMAS) was compared to the effectiveness observed in an implementation trial (IT) under routine care co...

BACKGROUND In the Placement of AoRTic TraNscathetER Valve (PARTNER) randomized controlled trial (RCT), which represented the first exposure to transapical transcatheter aortic valve replacement (TA-TAVR) for many clinical sites, high-risk patients undergoing TA-TAVR derived similar health-related quality of life (HRQoL) outcomes when compared with surgical aortic valve replacement (SAVR). With ...

OBJECTIVE To explore why reports that seem to describe randomised controlled trials are sometimes not indexed ("tagged") with RCT (randomised controlled trial) [pt] (publication type) in Medline. Design Cross sectional study. SETTING The Cochrane Collaboration and US National Library of Medicine worked together to identify and retag records of randomised controlled trials with RCT [pt], 1994 ...