Correspondence to: Y H Chan Tel: (65) 6317 2121 Fax: (65) 6317 2122 Email: chanyh@ cteru.gov.sg The prospective, randomised, controlled, blinded (if possible), sample-size calculated study with a preplanned statistical analysis and trial monitoring is undoubtedly the gold standard for a therapeutic or interventional clinical study. RCTs carried out recently have discredited some treatments deem...