Background Baseline clinical variables are prognostic for overall survival (OS) in patients with castration-resistant prostate cancer (CRPC). Their prognostic and predictive value with agents targeting bone metastases, such as radium-223, is not established. Patients and methods The radium-223 ALSYMPCA trial enrolled patients with CRPC and symptomatic bone metastases. Prognostic potential of ...

Becquerell has observed that p-rays change yellow phosphorus into red form. Ramsey* and Cameron* have shown that the radium emanation has destruotive and partial synthetic actions upon water, carbon monoxide, carbon dioxide, hydrogen chloride, and ammonia. The decomposing action of radium rays on the lecithin molecule has been observed by Schwara,4 Schaper,& and Werner.6 On the other hand, no s...

Radium-223 dichloride (radium-223) is an important therapeutic option for the treatment of patients with castration-resistant prostate cancer, symptomatic bone metastases, and no visceral disease. The unique mechanism of action of this first-in-class alpha-emitting radiopharmaceutical underlies its favorable safety profile and low incidence of myelosuppression. In the pivotal phase 3 ALpharadin...

Terrestrial surface waters and submarine ground water discharge (SGD) act as a source of dissolved substances for coastal systems. Solute fluxes SGD depend on the composition water-solid-microbe interactions close to sediment-water interface. Thus, this study aims characterize evaluate hydrogeochemical gradients developing in fresh-salt mixing zone Wismar Bay (WB), southern Baltic Sea, Germany....

The vertical activity concentration distributions of the radium isotopes, 226 Ra and 228 Ra, which are useful as radiotracers, were obtained for first time in western Subarctic Pacific Gyre (WSAG). It was possible to detect short-lived present from surface 400 m depth by analyzing large seawater samples. Low high concentrations layer WSAG strongly influenced upwelled deeper water with nutrients...

The present study was undertaken with a view of determining in a general way the effects of intravenous administration of radium upon the circulation and respiration. The problem was suggested to us by Dr. William J. Gies, under whose guidance a number of researches, dealing with the more extensive question of the action of radium upon animal and vegetable cells, have recently been carried on i...

Radium-223 is a first-in-class alpha particle-emitting radiopharmaceutical approved for the treatment of bone metastatic castration-resistant prostate cancer. Radium-223 is administered intravenously with no requirement for complex shielding and specifically targets areas of bone metastasis. In a randomized placebo-controlled Phase III study, treatment with radium-223 was shown to improve overa...