Abstract Machine learning (ML) algorithms have become popular in recent years and found increasing utility the field of medical imaging, specifically positron emission tomography (PET) imaging. The interest ML PET imaging for study neurodegenerative diseases stems from potential these techniques to analyze predict physiological parameters biomarkers such as total volume distribution (V $$_{\tex...

General linear time-invariant compartmental systems were examined to determine which systems meet the conditions necessary for application of the spectral analysis technique to the sum of the concentrations in all compartments. Spectral analysis can be used to characterize the reversible and irreversible components of the system and to estimate the minimum number of compartments, but it applies...

A procedure for the radiosynthesis of aliphatic [(18)F]trifluoromethyl groups by reacting 1,1-difluorovinyl precursors with [(18)F]fluoride ions, resulting in the equivalent of direct nucleophilic addition of H[(18)F]F, has been developed. A variety of (18)F-labelled model compounds were then obtained and two potential [(18)F]radiotracers were synthesised by a two step process starting from 1,1...