Abstract Introduction: Achievement of new drugs with minimal side effects is a important goal in the cancer treatment due to irreversible side effects of conventional drugs. Tricalcium phosphates as natural bone components have unique characteristics including excellent biocompatibility, high biosorption and superior bioactivity. This research aimed at investigating the inhibitory effect of tr...

In intensity-modulated radiotherapy (IMRT), a treatment is designed to deliver high radiation doses to tumors, while avoiding the healthy tissue. Optimizationbased treatment planning often produces sharp dose gradients between tumors and healthy tissue. Random shifts during treatment can cause significant differences between the dose in the “optimized” plan and the actual dose delivered to a pa...

introduction: breast conserving radiotherapy is one of the most common procedures performed in any radiation oncology department. a tangential parallel-opposed pair is usually used for this purpose. this technique is performed using 2d or 3d treatment planning systems. the aim of this study was to compare 2d treatment planning with 3d treatment planning in tangential irradiation in breast conse...

Background: The aim of this study was to develop and implement a Monte Carlo framework for evaluation of patient specific out-of-field organ equivalent dose (OED). Materials and Methods: Dose calculations were performed using a Monte Carlo-based model of Oncor linac and tomographic phantoms. Monte Carlo simulations were performed using EGSnrc user codes. Dose measurements were performed using r...

Introduction: In this study, dose distribution of the chest wall in post-mastectomy breast cancer patients was evaluated and compared in the tangential wedged beam (TWB) and field-in-field (FIF) plans. Materials and Methods: Thirty-six patients with left-sided breast cancer were enrolled in this study. The FIF and TWB plans were generated for each patient to compare dosimetric parameters of th...

ADAPTIVE RADIATION THERAPY OF PROSTATE CANCER by NING WEN August 2010 Advisor: Dr. Teamour Nurushev Major: Medical Physics Degree: Doctor of Philosophy ART is a close-loop feedback algorithm which evaluates the organ deformation and motion right before the treatment and takes into account dose delivery variation daily to compensate for the difference between planned and delivered dose. It also ...

The sodium/bile acid cotransporter NTCP was recently identified as a receptor for hepatitis B virus (HBV). NTCP is glycosylated and the role of glycans in protein trafficking or viral receptor activity is not known. NTCP contains two N-linked glycosylation sites and asparagine amino acid residues N5 and N11 were mutated to a glutamine to generate NTCP with a single glycan (NTCP-N5Q or NTCP- N11...

AIMS AND OBJECTIVES Aims and objectives of this study are to get the best fit of the normal tissue tolerance doses to the NTCP model of the linear quadratic model. METHODS AND MATERIALS To compute the NTCP, the modified form of the Poisson cell kill model of NTCP, based on linear-quadratic model, is used. The model has been applied to compute the parameters of the NTCP model using clinical to...

PURPOSE To compare the clinical benefit of robust optimized Intensity Modulated Proton Therapy (minimax IMPT) with current photon Intensity Modulated Radiation Therapy (IMRT) and PTV-based IMPT for head and neck cancer (HNC) patients. The clinical benefit is quantified in terms of both Normal Tissue Complication Probability (NTCP) and target coverage in the case of setup and range errors. MET...

Lung cancer is the leading cause of cancer-related deaths worldwide. Radiotherapy is one of the main treatment modalities of lung cancer. However, the achievable accuracy of radiotherapy treatment is limited for lung-based tumors due to respiratory motion. Four-dimensional (4D) radiotherapy explicitly accounts for anatomic motion by characterizing the motion, creating a treatment plan that acco...