OBJECTIVE This continuing education article reviews radionuclide bone therapy agents that are available commercially and introduces agents that are being evaluated for future use. Currently these agents are used to provide pain palliation from metastases to bone. Future applications may include adjuvant therapy to surgery or external beam treatment. After reading this paper, the reader should b...

Abstract Background For radiopharmaceuticals, aseptic preparation in combination with filtration is the most commonly used sterilizing method. In general, production of radiopharmaceuticals needs to fulfil requirements good manufacturing practice. scope this work, we focused on positron emitter gallium-68 and therapeutically beta- gamma-emitter lutetium-177, as they are routinely for in-house s...

The chemistry of lSF has the reputation of being difficult and this is to a large extent supported by a survey of the literature, where there are many reports of reactions involving 18F where the yields are low and the reactions erratic. However, in the nine years since the last review of the chemistry of ~8F in this journal °) considerable progress has been made in understanding and controllin...

A fundamental task within the framework of a project searching for new radiopharmaceuticals for systemic therapy was the evaluation of the capabilities of the Portuguese Research Reactor (RPI) for the production of several important radionuclides. The feasibility of producing 64Cu, 77As, 153Sm, 165Dy, 166Ho, 170Tm, 177Lu, 186Re, 199Au and 111Ag in useful quantities was evaluated for the present...

Quality control (QC) procedures should always be performed following radiopharmaceutical preparation and prior to patient administration. The main aim of QC is to ensure optimal radiopharmaceutical product properties except for some short half-life tracers such as some positron emission tomography (PET) imaging probs. by dispensing a radiopharmaceutical of the highest quality the risk of having...

The ever-growing need for radiopharmaceuticals, i.e., compounds containing pharmaceutical drugs and radioisotopes used medical diagnostic imaging (SPECT/PET scan) treating neoplasms, is significantly leading to an increased demand such substances in hospitals clinics worldwide. Currently, most large-scale productions of required radiopharmaceuticals are carried out research reactors, via the fi...

In spite of considerable progress, much remains to be done in the estimation of absorbed doses to organs and tissues in the body and in the prediction of biological effects from radiopharmaceuticals. In patients undergoing diagnostic procedures, the biokinetics of the radionuclide has to be determined for a number of representative patients. When radiopharmaceuticals are used for therapy, it is...