w Myocardial perfusion imaging (MPI) in acute myocardial infarction (MI) has had its ups and downs over the past 4 decades (1). “Cold-spot” imaging with thallium-201, technetium-99m tetrofosmin and sestamibi, wall motion assessment with gated radionuclide angiography, and “hot-spot” imaging with radionuclide-bound pyrophosphate, glucarate, antimyosin, annexin V (2), and more recently, duramycin...

Radiopharmaceuticals for molecular imaging involve careful consideration of the following two factors: radionuclide selection and specificity to the molecular target. In selecting a radionuclide, the specific decay mode, physical half-life, chemical properties, and method of production must be considered. For proper design of a radiopharmaceutical which targets a specific biological or disease ...

The present study examines the extent of spinal cerebrospinal fluid (CSF) absorption in healthy individuals in relation to physical activity, CSF production, intracranial pressure (ICP), and spinal CSF movement. Thirty-four healthy individuals aged 21-35 yr were examined by lumbar puncture and radionuclide cisternography with repeated imaging. ICP was registered before and after CSF drainage, a...

Somatostatin (SST) receptors (SSTRs) belong to the typical 7-transmembrane domain family of G-protein-coupled receptors. Five distinct subtypes (termed SSTR1-5) have been identified, with SSTR2 showing the highest affinity for natural SST and synthetic SST analogs. Most neuroendocrine tumors (NETs) have high expression levels of SSTRs, which opens the possibility for tumor imaging and therapy w...

Over the past decades, the diagnostic methods and therapeutic tools for thyroid cancer (TC) have been greatly improved. In addition to the classical method of ingestion of radioactive iodine-131 (I131) and subsequent I123 and I124 positron emission tomography (PET) in therapy and examination, I124 PET-based 3-dimensional imaging, Ga68-labeled [1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetra...

Radionuclide myocardial perfusion imaging (MPI) is an established and non-invasive imaging technique with diagnostic and prognostic efficacy in the investigation of coronary artery disease. It is the only widely available test for assessing myocardial perfusion directly but there are variations in the way it is performed in different centres. Harmonization of practice, at least at a national le...

Skeletal scintigraphy is, in addition to plain radiography, the most important method for diagnosing inflammatory skeletal disease. It is important for the localisation of inflammation as well as for its highly negative, predictive value. The patients reported in this study were examined by three-phase scintigraphy by which the inflammatory process was detected in soft tissue (hyperaemia) in th...

the features of hypertrophic pulmunary osteoarthropathy (hpoa) on radionuclide bone scintigraphy have been well described in case reports and small series of patients. the aim of this study was to investigate prospectively the prevalence and distribution of hpoa in a large series of patients with carcinoma of the lung. two hundred and eleven patients aged 31-89 years (average age 66 years) male...

From the prospective and outcome-based studies that have been carried out in the past few years, the following conclusions regarding the diagnostic evaluation of patients with suspected PE can be made: 1. A normal V/Q scan interpretation excludes the diagnosis of clinically significant PE. 2. Patients with a very-low- or low-probability V/Q scan interpretation and a low clinical likelihood of P...

There are numerous imaging tests for diagnosing musculoskeletal infection. Radiographs are routinely performed, because even when not diagnostic, they provide an anatomic overview of the region of interest that could influence subsequent procedure selection and interpretation. MRI is sensitive and provides superb anatomic detail. Bone scintigraphy accurately diagnoses osteomyelitis in bones not...