Investigating the volume status before contrast nephropathy studies Sir, We read with great interest the original article by Drager et al. [1] about the mechanism of a protective effect of N-acetylcysteine (NAC) against contrast-induced nephrop-athy (CIN) in patients undergoing elective coronary angio-graphy. This study assessed pre-and post-radiocontrast NAC effects on specific oxidative stres...

1. Yıldız E, Köse M, Yürüyen G, Akpınar TS, Emet S, Erdem E, et al. Relationship between brain natriuretic peptide, microalbuminuria, and contrast-induced nephropathy in patients with acute coronary syndrome. Anatolian J Cardiol 2014; 14: 505-10. [CrossRef] 2. Barrett BJ, Parfrey PS. Prevention of nephrotoxicity induced by radiocontrast agents. N Engl J Med 1994; 331: 1449-50. [CrossRef] 3. Par...

BACKGROUND The clinical use of iodinated radiocontrast agents or gadolinium for renal perfusion imaging is limited in the presence of renal dysfunction. We have previously demonstrated the feasibility of hemodynamic response imaging (HRI), a functional magnetic resonance imaging (MRI) method combined with hypercapnia and hypercapnic-hyperoxia, for monitoring changes in liver perfusion and hemod...

BACKGROUND The nephrotoxicity induced by contrast media remains a serious clinical problem, and the underlying mechanism has not been completely understood. Experimental and clinical investigations suggest that reactive oxygen species (ROS) are critical determinants of radiocontrast nephropathy (RCN), and that antioxidants can prevent this damage. METHODS Cultured human proximal renal tubule ...

How Important Is the Problem? Over 70 million computed tomography (CT) scans are performed yearly in the United States, approximately half of which use iodinated radiocontrast media, and over 2 million patients undergo other studies using radiocontrast media such as coronary angiograms. Contrastinduced acute kidney injury (CI-AKI) is one of the major risks of procedures using radiocontrast medi...

OBJECTIVES Urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 predict the development of acute kidney injury following renal insults of varied aetiology. To aid clinical interpretation, we describe the kinetics of biomarker elevations around an exposure. DESIGN In an ancillary analysis of the multicenter SAPPHIRE study, we examined the kinetics of...