نتایج جستجو برای: radiobiological modelling

تعداد نتایج: 163342  

2009
David J. Brenner

There is strong evidence that ionizing radiation increases cancer risks at high doses (e.g., >1 Gy), and persuasive, if controversial, epidemiological evidence that cancer risks are increased at low doses ( 10 mGy). Discussed here are the issues related to extrapolating radiation risks from low radiation doses to very low doses (<1 mGy) — for which purpose we are forced to rely on radiobiologic...

This commentary considers the positive and negative consequences of early economic modelling and explores potential future directions. Early economic modelling offers device manufacturers an opportunity to assess the potential value of an innovation at an early stage of development. Early modelling can direct resources into potentially viable technologies and reduce inv...

Journal: :Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti 2013
J Kubeš B Ondrová P Vítek S Vinakurau

Radiotherapy techniques in the last decade evolved to the stage where the potential dose distribution significantly differs from earlier practices. Rotational IMRT, robotic radiotherapy or proton radiotherapy enables extremely precise dose delivery to target volumes, on the other hand, these techniques can yield a number of problems. As for photon radiotherapy, this concerns primarily the effec...

Journal: :Journal of radiation research 2009
Tom K Hei Leslie K Ballas David J Brenner Charles R Geard

Recent developments in microbeam technology have made drastic improvements in particle delivery, focusing, image processing and precision to allow for rapid advances in our knowledge in radiation biology. The unequivocal demonstration that targeted cytoplasmic irradiation results in mutations in the nuclei of hit cells and the presence of non-targeted effects, all made possible using a charged ...

Journal: :Journal of virology 1978
E Henderson L Heston E Grogan G Miller

Lymphocyte transforming properties of B95-8 strain Epstein-Barr virus (EBV) are very sensitive to inactivation by either UV or X irradiation. No dose of irradiation increases the transforming capacity of EBV. The X-ray dose needed for inactivation of EBV transformation (dose that results in 37% survival, 60,000 rads) is similar to the dose required for inactivation of plaque formation by herpes...

2003
Gerhard Kraft

The radiobiological effects of highly-charged-ion beams are of interest for tumortherapy and for radioprotection in space. In tumor therapy, high-energy protons and carbon ions exhibit an inverse dose profile, i.e. an increase of energy deposition with penetration depth. This allows a greater tumor dose for protons and carbon ions than for photons. In addition, for the heavier carbon ions, this...

Abstract Purpose-The purpose of this paper is to review a sample of the literature relating to Interpretive Structural Modelling (ISM) and its deployment for modelling purposes in the area of supply chain management (SCM). Design/methodology/approach- The literature is examined from the three perspectives. First, concept of ISM and examines ISM as modelling technique. Second, use of ISM by ...

Journal: :The British journal of radiology 2005
K N Prasad

Health risks of low doses of ionizing radiation (10 cGy or less) may not be accurately estimated in humans by epidemiological study or mathematical modelling because of several inherent confounding factors including environmental, dietary and biological variables that cannot be accounted for in any radio-epidemiological study. In addition, the expression of radiation-induced damage in humans no...

2010
D Abeyaratne Peter MacCallum

Purpose: In recent years interest has grown in the investigation and clinical application of intensity modulated radiation therapy (IMRT) for adjuvant treatment of early stage breast cancer. A review of the current literature was conducted to establish if IMRT can reduce doses delivered to the heart and potentially minimise the likelihood of cardiac toxicities for early stage left-sided breast ...

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