background: in order to deliver the precise dose to the target in radiotherapy, absorbed dose to water at the reference point should be assessed. when the calibration procedure is performed for a reference dosimeter in the 60co beam of a secondary standard dosimetry laboratory (ssdl), the total uncertainty in absorbed dose to water (dw) is estimated to be approximately 1.5%. this study attempts...

This article discusses the natural history, clinical epidemiology, diagnosis, and treatment of radiation-induced lung diseases (RILDs). Furthermore, we review current experimental developments and assess potential areas for future investigation. Radiation therapy (RT) is a key component of the approach to the treatment of thoracic neoplasms. The use of radiation for the treatment of cancer expl...

PURPOSE Magnetic resonance imaging-guided radiation therapy has entered clinical practice at several major treatment centers. Treatment of early-stage non-small cell lung cancer with stereotactic body radiation therapy is one potential application of this modality, as some form of respiratory motion management is important to address. We hypothesize that magnetic resonance imaging-guided tri-co...

Radiation therapy for advanced Hodgkin's disease often requires large fields and may result in significant exposure of normal tissues to ionizing radiation. In long-term survivors, this may increase the risk for late toxicity including secondary malignancies. 3DCRT has been successfully used to treat this disease but treatment delivery is often complex requiring matching of photon with electron...

The ultimate goal of radiation therapy is to efficiently deliver radiation in order to eradicate tumors, while adequately sparing nearby normal tissues. With the emergence of advanced technologies in radiation delivery, more and more conformal radiation delivery has been achieved in order to overcome challenges such as motion management between treatment fractions as well as during radiation de...

Radiotherapy (RT), used for the treatment of cancers, such as lung cancer, lymphoma, breast cancer, bone marrow transplantation, and esophageal cancer, causes the exposure of lungs to radiation. Since the lungs are very sensitive to ionizing radiation, radiation-induced lung diseases due to radiation therapy are usually common. In this article, lung diseases secondary to RT and the diagnosis an...

Background: Radiation‐induced acute lung damages are refractory side effects in lung cancer radiotherapy (RT). Prospective study investigates the possible role of piperine (Pip) as anti-inflammatory agent against γ-rays-induced lung tissue lesions in an applicable rat model. Materials and Methods: Fifty-six Sprague-Dawley rats were divided into four groups: Control, rats were administered...

PURPOSE Technological developments in radiation therapy result in smaller irradiated volumes of normal tissue. Because the risk of radiation therapy-induced toxicity generally depends on irradiated volume, changing volume could change the dose-limiting toxicity of a treatment. Recently, in our rat model, we found that early radiation-induced lung dysfunction (RILD) was closely related to irradi...

Stereotactic radiation approaches are gaining more popularity for the treatment of intracranial as well as extracranial tumors in organs such as the liver and lung. Technology, rather than biology, is driving the rapid adoption of stereotactic body radiation therapy (SBRT), also known as stereotactic ablative radiotherapy (SABR), in the clinic due to advances in precise positioning and targetin...