A uniquely structured 65 amino acid helix-loop-helix′-loop-helix′′ three-R-helix bundle, R3-1, was designed and chemically synthesized, using the crystallographically characterized three stranded coiled coil “Coil-Ser”, as a starting point. The circular dichroism spectrum of R3-1 has a typical R-helical signature, with a [θ]222 ) -22 600 deg‚cm2‚dmol-1, indicating a 80.5% R-helical content. Sed...

Esophageal cancer is one of the leading causes of mortality worldwide. Although, surgery, radio- and chemotherapy are used to treat the disease, the identification of new drugs is crucial to increase the curative effect. The aim of the present study was to examine the chemotherapeutic sensitizing effect of nimotuzumab (h-R3) and cisplatin cytotoxic drugs cisplatin (DDP) and 5-fluorouracil (5-FU...

In this paper, we study the following fractional Schrödinger-poisson systems involving fractional Laplacian operator { (−∆)su+ V (|x|)u+ φ(|x|, u) = f(|x|, u), x ∈ R3, (−∆)tφ = u2, x ∈ R3, (1) where (−∆)s(s ∈ (0, 1)) and (−∆)t(t ∈ (0, 1)) denotes the fractional Laplacian. By variational methods, we obtain the existence of a sequence of radial solutions. c ©2016 All rights reserved.

and Applied Analysis 3 whereQ is a fixed positive definite matrix and k ≥ 3. Then, one has the following Lyapunov functions V n (x) = R2 (x) + R3 (x) + ⋅ ⋅ ⋅ + Rn (x) 1 + Q 1 (x) + ⋅ ⋅ ⋅ + Q n−2 (x) . (3) Proof. Rewrite V n (x) = R2 (x) + R3 (x) + ⋅ ⋅ ⋅ + Rn (x) 1 + Q 1 (x) + ⋅ ⋅ ⋅ + Q n−2 (x) = ∑ ∞

Due to the ever growing amount of content in the Web of Data, the retrieval of relevant information is challenging. Currently, efficient resource recommendation methods are lacking, that could ease the exploration of data in the Web of Data. To alleviate this situation, this paper proposes the R3 resource recommendation framework for retrieval of data in the Linked Open Data (LOD) cloud. It ana...

Self-aggregation of the microtubule-binding protein Tau reduces its functionality and is tightly associated with Tau-related diseases, termed tauopathies. Tau aggregation is also strongly associated with two nucleating six-residue segments, namely PHF6 (VQIVYK) and PHF6* (VQIINK). In this paper, using experiments and computational modeling, we study the self-assembly of individual and binary mi...

Avena fatua (wild oat) populations with resistance (R) to one or more herbicides have been described in numerous cropping systems worldwide. We previously reported that the R3 and R4 wild oat populations from Montana, USA, were resistant to four herbicides representing three different modes of action: tralkoxydim [acetyl-CoA carboxylase (ACCase] inhibitor), imazamethabenz and flucarbazone [acet...

Microtubules interact strongly with the viral movement protein (MP) of Tobacco mosaic virus (TMV) and are thought to transport the viral genome between plant cells. We describe a functionally enhanced DNA-shuffled movement protein (MP(R3)) that remained bound to the vertices of the cortical endoplasmic reticulum, showing limited affinity for microtubules. A single amino acid change was shown to...

BACKGROUND Polarity of the Drosophila compound eye arises primarily as a consequence of two events that are tightly linked in time and space: fate specification of two photoreceptor cells, R3 and R4, and the subsequent directional movement of the unit eyes of the compound eye, or ommatidia. While it is thought that these fates dictate the direction of ommatidial rotation, the phenotype of mutan...

BACKGROUND Video-assisted thoracoscopic sympathicotomy has been determined to be the best way to treat palmar hyperhidrosis. However, satisfaction with the surgical outcomes decreases with the onset of compensatory hyperhidrosis (CH) over time. The ideal level of sympathicotomy is controversial. Therefore, we compared the long-term results of R3 and R4 sympathicotomy. METHODS We retrospective...