Quinones are widely distributed substances of often potential toxicological significance. On the other hand, cyclic AMP is known to promote a cell-survival response and to retard apoptosis [Berridge, Tan and Hilton (1993) Exp. Hematol. 21, 269-276]. Therefore the effects of quinones on adenylate cyclase were tested. Adenylate cyclase is rapidly inhibited by quinones, with IC50 values of 40-45 m...

The reduction of the following exogenous quinones by succinate and NADH was studied in mitochondria isolated from both wild type and ubiquinone (Q)-deficient strains of yeast: ubiquinone-0 (Q0), ubiquinone-1 (Q1), ubiquinone-2 (Q2), and its decyl analogue 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone (DB), duroquinone (DQ), menadione (MQ), vitamin K1 (2-methyl-3-phytyl-1,4-naphthoquinone), th...

Photoreactions of quinones with alkynes under catalytic and non-catalytic conditions were studied. Contrary to recent reports, simple irradiation blue light is sufficient trigger the [2+2] photocycloadditions, which afford...

Running across Enron Field during the Owls' baseball game on Friday seemed like a ha rmless prank to Jose De La Pena. But it laiided the Baker College senior in jail for the night, and he may face fines of up to $2,500. At the game, a group of about 25 Baker students, including De \ x Pena, along with Baker Master Mickey Quinones were sitting on the third base line. Quinones had purchased ticke...

The transcriptional regulator QsrR is converted into a genetically encoded fluorescent probe capable of ratiometric monitoring of quinones in living cells with high sensitivity and selectivity.

A series of highly functionalized quinones was prepared by an original reaction of 2,3-bis(chloromethyl)-1,4-dimethoxyanthraquinone (6) with various nitronate anions under electron transfer reaction conditions.