A new series of fluorinated quinoline -1,4-dithiones 3(a-f) were obtained by the treatment 3-aryl-2-hydrazino-quinolines 1(a-f) with isobenzo furan-1,3-dithione 2 in presence p- toluene sulphonic acid (PTSA) solid state at room temperature as one pot. All products are monitored TLC and isolated GC furthermore confirmed spectral analysis.

Alkenyl boronate complexes react with acylated quinolines and isoquinolines via 1,2-metalate rearrangement to give alkylated, dearomatized heterocycles in good yields, diastereoselectivities, regioselectivities. This multi-component coupling is highly modular can be used access a wide scope of heterocyclic scaffolds. Chiral boronic esters made through this methodology possess high synthetic pot...

We report the synthesis of quinolines using cyclopropenes and an azidobenziodazolone (ABZ) hypervalent iodine reagent as azide radical source under visible-light irradiation. Multisubstituted quinoline products were obtained in 34–81% yield. The reaction was most efficient for 3-trifluoromethylcyclopropenes, affording valuable 4-trifluoromethylquinolines. transformation probably proceeds throug...

Biologically active heterocyclic compounds comprise of largest & manifold family organic compounds. These include Quinolines, Quinazolines, Aminoquinolines, etc and their derivatives. They exhibit multi-faceted biological properties like analgesic, anti-inflammatory, anticonvulsant, antibacterial, antifungal, antidepressant, anticancer, antitubercular &antihistaminic. are considered to ...

Ruthenium complexes are remarkable catalysts for the C–H activation approaches and organic transformations. Combining a Ru-catalyst with oxidants other additives in one-pot process is considered sustainable approach due to reduction reaction steps minimal usage of solvents during synthesis, work-up, isolation chemicals, purification products. This review highlights ruthenium-catalyzed transform...

The title hydrate, C(27)H(23)NO(2)·H(2)O, features an almost planar quinoline residue (r.m.s. deviation = 0.015 Å) with the benzene [dihedral angle = 63.80 (7) °] and chalcone [C-C-C-O torsion angle = -103.38 (18)°] substituents twisted significantly out of its plane. The configuration about the C=C bond [1.340 (2) Å] is E. In the crystal, mol-ecules related by the 2(1) symmetry operation are l...

In the title compound, C(19)H(16)ClNO(2), the dihedral angle between the plane of the phenyl substituent and 3-acetyl-quinoline unit is 75.44 (5)°. The crystal structure is stabilized by inter-molecular C-H⋯O hydrogen bonds.

In the title hydrated salt, C11H12NO(+)·Cl(-)·2H2O, the quinoline ring system is essentially planar, with a maximum deviation of 0.005 (1) Å for all non-H atoms. In the crystal, the three components are linked by O-H⋯O, N-H⋯O, O-H⋯Cl and weak C-H⋯O hydrogen bonds, forming a layer structure parallel to the ac plane. The crystal structure is further stabilized by π-π stacking inter-actions, with ...

In the title compound, C(15)H(15)NO(4), the quinoline ring system and one of the malonate side chains are essentially coplanar (r.m.s. deviation = 0.0297 Å). The two malonate C-C(=O)-O-CH(3) side chains are oriented at right angles [89.68 (8)°] with respect to each other. The crystal packing is stabilized by weak non-classical inter-molecular C-H⋯O hydrogen bonds, which link the mol-ecules into...